Figure 4

Adherence to ABC monotherapy. A. Long-term effects of adherence to ABC monotherapy, using the prescribed adherence breaks. The wild type (solid blue curve, left axes) and mutant (dashed green curve, right axes) populations are shown. The overall effect of the mutant remains low. Parameters used, in addition to those in Table 1, were n _I = 262.5 day^-1, ω = 0.7, r _I = 0.01 day^-1, r _Y = 0.001 day^-1, d _V = 3 day^-1, d _S = 0.1 day^-1, d _I = 0.5 day^-1, ψ = 0.2, p _L = 0.05, r _R = r _Q = 80 μM ^-1, day^-1, λ = 180 cells μL ^-1 and m _RI = m _RY = log(2) day^-1. Initial conditions were V _I (0) = 22000 virions mL^-1, V _Y (0) = 5 × 10^-3 virions mL^-1, T _S (0) = 1000 cells day^-1 and all other initial conditions were zero. B. The effects of missing one extra dose per drug holiday. The proportions of each type of uninfected T cell at the end of the simulation are shown in the insets.