Table 5 Comparison of host and bacteriological characteristics between isoniazid resistant isolates with katG315Thr mutations and other mutation/wild type
| Â | Â | No. of isolates with: | Â | Â | |
|---|---|---|---|---|---|
Variables | katG315Thr n= 74 | Others n= 57 | χ2 | p | |
Sputum smear | Negative | 23(31.1) | 26(45.6) | 2.905 | 0.088 |
| Â | Positive | 51(68.9) | 31(54.4) | Â | Â |
Treatment history | New | 41(55.4) | 39(68.4) | 2.294 | 0.13 |
| Â | Previously | 33(44.6) | 18(31.6) | Â | Â |
Cavity | No | 59(79.7) | 52(91.2) | 3.291 | 0.07 |
| Â | Yes | 15(20.3) | 5(8.8) | Â | Â |
Drug resistance profile | Others | 38(51.4) | 40(70.2) | 4.736 | 0.030* |
| Â | MDR-TB | 36(48.6) | 17(29.8) | Â | Â |
rpoB mutation | No | 39(52.7) | 43(75.4) | 7.11 | 0.008* |
| Â | Yes | 35(47.3) | 14 (24.6) | Â | Â |
Clustered | No | 20(27.0) | 48(84.2) | 42.18 | 0.001* |
| Â | Yes | 54(73.0) | 9(15.8) | Â | Â |
Beijing family | No | 9(12.2) | 17(29.8) | 6.314 | 0.012* |
| Â | Yes | 65(87.8) | 40(70.2) | Â | Â |