Extensive transmission of isoniazid resistant M. tuberculosis and its association with increased multidrug-resistant TB in two rural counties of eastern China: A molecular epidemiological study

Table 4 Binary logistic regression analysis on the associations between demographical, clinical and bacteriological characteristics and clustering of INH resistant MTB isolates in the present study

Variables		INH resistant isolates		unadjusted OR	adjusted OR*	p	95%CI
		No. patients	n(%) clustered
Social-demographic and clinical characteristics:
Age (year)	18~	34	12(35.3)	1
	30~	65	34(52.3)	2.011
	60~	32	17(53.1)	2.078
Sex	Female	46	22(47.8)	1
	Male	85	41(48.2)	1.163
County	Deqing	55	27(49.1)	1
	Guanyun	76	36(47.4)	0.933
BMI	≥18.5	94	41(43.6)	1	1
Index	<18.5	37	22(59.5)	1.896	1.833	0.13	0.836-4.019
Treatment	New	80	32(40.0)	1	1
history	Previously	51	31(60.8)	2.325	2.159	0.040^§	1.037-4.495
Sputum	negative	49	18(36.7)	1	1
smear	positive	82	45(54.9)	2.095	2.286	0.032^§	1.075-4.863
Cavity	No	111	50(45.0)	1	1
	Yes	20	13(65.0)	2.266	2.423	0.091	0.868-6.761
Bacteriological features:
Drug	INH mono	55	21(38.2)	1	1
resistance	MDR-TB	53	31(58.5)	2.281	2.384	0.030^§	1.089-5.220
	PDR -TB	23	11(47.8)	1.484	1.627	0.348	0.588-4.496
katG	wt	50	9(18.0)	1	1
	315Thr	74	54(73.0)	12.3	12.7	0.001^§	6.357-14.80
	others	7	0(0)	-	-
inhA	wt	103	59(57.3)	1	1
	-15T	28	4(14.3)	0.124	0.12	0.001^§	0.038-0.375
Beijing	No	26	4(15.4)	1	1
genotype	Yes	105	59(56.2)	5.183	5.289	0.001^§	1.832-15.26

NOTE. OR, odds ratio; 95%CI, confidence interval; wt, wild type; MDR-TB, multidrug-resistant tuberculosis; PDR-TB, polydrug-resistant tuberculosis.
*: OR and 95%CI were adjusted by age, sex and county of subjects in binary logistic regression model.
§: p < 0.05.

ISSN: 1471-2334