Extensive transmission of isoniazid resistant M. tuberculosis and its association with increased multidrug-resistant TB in two rural counties of eastern China: A molecular epidemiological study

Table 2 Genetic mutations and their frequencies related to INH resistance in MTB isolates from the study sites

Drug resistance	Total	katG315Ser → *			inhA-15C→ *	katG+	wt
Profile		Arg	Asn	Thr	T	*inhA* ^§
H	55	2	1	28	12	0	12
MDR-TB
HR	32	0	1	19	6	1	5
HRS	12	0	0	9	2	1	0
HRE	5	0	0	5	0	0	0
HRSE	4	0	1	2	1	0	0
PDR-TB
HS	13	0	0	5	3	0	5
HE	2	0	0	0	1	0	1
HSE	8	0	1	5	1	0	1

NOTE: H, isoniazid; R, rifampicin; S, streptomycin; E, ethambutol.
MDR-TB, multidrug-resistant tuberculosis; PDR-TB, polydrug-resistant tuberculosis.
*: No. of isolates with mutations in single gene.
§: No. of isolates with mutations in multiple genes. Two INH resistant isolates shared the mutation in katG and inhA gene simultaneously: one with katG315Thr and inhA-15T mutations and the other with katG315Arg and inhA-15T mutation.

ISSN: 1471-2334