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Table 3 Pattern of gene mutations detected by Genotype MTBDRplus assay in drug resistant M. tuberculosis strains

From: Rapid screening of MDR-TB using molecular Line Probe Assay is feasible in Uganda

Gene

Band

Gene region or mutation

MDR strains*

(n = 13)

RIF monoresistant strains*

(n = 6)

INH monoresistant

strains*

(n = 13)**

rpoB

     
 

WT1

506-509

   
 

WT2

510-513

 

1

 
 

WT3

513-517

1

2

 
 

WT4

516-519

 

1

 
 

WT5

518-522

   
 

WT6

521-525

   
 

WT7

526-529

1

1

 
 

WT8

530-533

1

1

 
 

MUT1

D516V

   
 

MUT2A

H526Y

   
 

MUT2B

H526D

1

  
 

MUT3

S531L

9

1

 

katG

     
 

WT

315

1

 

1

 

MUT1

S315T1

9

 

7

 

MUT2

S315T2

   

inhA

     
 

WT1

-15/-16

1#

  
 

WT2

-8

   
 

MUT1

C15T

2

 

1

 

MUT2

A16G

   
 

MUT3A

T8C

   
 

MUT3B

T8A

   
  1. * by conventional drug susceptibility testing (MGIT DST)
  2. 1 MDR strain had both rpoB WT3 and WT4 mutations, 1 MDR had both rpoB WT4 and WT7 mutations.
  3. # this strain also had katG S315T1 mutation.
  4. 1 MDR strain did not have mutation in either katG or inhA.
  5. ** 4 INH mono-resistant strains had no mutations detected in inhA or katG.
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BMC Infectious Diseases

ISSN: 1471-2334

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