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Table 3 Pattern of gene mutations detected by Genotype MTBDRplus assay in drug resistant M. tuberculosis strains

From: Rapid screening of MDR-TB using molecular Line Probe Assay is feasible in Uganda

Gene Band Gene region or mutation MDR strains*
(n = 13)
RIF monoresistant strains*
(n = 6)
INH monoresistant
strains*
(n = 13)**
rpoB      
  WT1 506-509    
  WT2 510-513   1  
  WT3 513-517 1 2  
  WT4 516-519   1  
  WT5 518-522    
  WT6 521-525    
  WT7 526-529 1 1  
  WT8 530-533 1 1  
  MUT1 D516V    
  MUT2A H526Y    
  MUT2B H526D 1   
  MUT3 S531L 9 1  
katG      
  WT 315 1   1
  MUT1 S315T1 9   7
  MUT2 S315T2    
inhA      
  WT1 -15/-16 1#   
  WT2 -8    
  MUT1 C15T 2   1
  MUT2 A16G    
  MUT3A T8C    
  MUT3B T8A    
  1. * by conventional drug susceptibility testing (MGIT DST)
  2. 1 MDR strain had both rpoB WT3 and WT4 mutations, 1 MDR had both rpoB WT4 and WT7 mutations.
  3. # this strain also had katG S315T1 mutation.
  4. 1 MDR strain did not have mutation in either katG or inhA.
  5. ** 4 INH mono-resistant strains had no mutations detected in inhA or katG.