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Table 2 Random-effect linear regression analyses of trend of CD4 count (slope, cells/μL per year)

From: Trends in CD4 counts in HIV-infected patients with HIV viral load monitoring while on combination antiretroviral treatment: results from The TREAT Asia HIV Observational Database

 

Univariate

Multivariate**

 

Difference*

(95% CI)

p value

Difference*

(95% CI)

p value

Sex

      

Male*

0.0

  

0.0

  

Female

9.5

(0.1, 18.9)

0.047

7.8

(-1.5, 17.2)

0.099

Current age

      

per 10 years older

-6.5

(-10.3, -2.7)

0.001

-4.8

(-8.6, -1.0)

0.013

Disease stage

      

CDC Category A*

0.0

  

0.0

  

TB with or without other ADI

24.4

(13.7, 35.1)

< 0.001

26.3

(15.6, 37.0)

< 0.001

Non-TB ADI(s)

3.7

(-5.6, 13.0)

0.433

12.0

(2.5, 21.4)

0.013

Haemglobin level

      

per 1 g/dL higher

0.0

(-0.0, 0.1)

0.661

0.0

(-0.0, 0.1)

0.689

Concurrent CD4 count

      

Per 100 cells/μL higher

1.3

(-0.3, 3.0)

0.116

1.9

(0.2, 3.7)

0.033

Concurrent viral load

      

per log10 copies/mL higher

-40.9

(-48.7, -33.2)

< 0.001

-40.5

(-48.4, -32.6)

< 0.001

Hepatitis B or C coinfection

      

No*

0

  

0

  

Yes

-19.1

(-31.1, -7.0)

0.002

-17.7

(-29.7, -5.7)

0.004

Time since cART initiation

      

> 6 to ≤ 12 months*

0.0

  

0.0

  

> 12 to ≤ 18 months

-21.3

(-37.7, -5.0)

0.011

-21.5

(-37.8, -5.2)

0.010

> 18 to ≤ 24 months

-23.1

(-39.3, -7.0)

0.005

-25.8

(-42.0, -9.7)

0.002

> 24 or more months

-58.0

(-70.3, -45.7)

< 0.001

-59.1

(-71.7, -46.5)

< 0.001

Initial cART containing NNRTI

      

No*

0.0

  

0.0

  

Yes

6.4

(-1.4, 14.1)

0.106

-1.3

(-9.2, 6.6)

0.749

Initial cART containing boosted PI

      

No*

0.0

  

0.0

  

Yes

-0.8

(-10.5, 9.0)

0.880

-3.4

(-13.2, 6.3)

0.493

Initial cART containing abacavir

      

No*

0.0

     

Yes

-12.9

(-25.8, 0.0)

0.050

-5.6

(-18.5, 7.3)

0.397

  1. * Difference were compared with the first category of each categorical variable.
  2. ** Constant term for multivariate model: 205.5 (174.4, 236.6) cells per μL per year.