Skip to main content

Table 2 Number of mutations, genetic distance, dN, dS and dN/dS.

From: Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response

Regions and types of treatment response

nt mutations

aa

mutations

Genetic distance ws

Genetic distance bs

dS ws

dS bs

dN ws

dN bs

dN/dS ws

dN/dS bs

NS5A

          

SVR

29.85

7.03

0.022

0.064

0.0739

0.2519*

0.0075

0.0182*

0.0876

0.0672*

NR

13.41

4.65

0.01

0.053

0.0272

0.2075*

0.0054

0.0155*

0.1365

0.0761*

ETR

26.21

5.77

0.0193

0.056

0.0506

0.2128*

0.0061

0.0164*

0.0759

0.0734*

CRS

          

SVR

1.65

0.44

0.0203

0.055

0.1451

0.3114* b

0.0192

0.0412*

0.1382* a

0.1181*

NR

0.75

0.20

0.0093

0.044

0.0769

0.2303* c

0.0239

0.0203*

0.2917* a

0.0796*

ETR

1.25

0.26

0.0155

0.037

0.119

0.1797* b, * c

0.0233

0.0223*

0.1596

0.1010*

PKR-bd

          

SVR

5.21

1.23

0.0263

0.062

0.1308

0.2955*

0.0156

0.0171*

0.1028

0.0376* b

NR

2.08

0.85

0.0105

0.055

0.042

0.2857*

0.0156

0.0147*

0.4569

0.0390* c

ETR

3.55

0.73

0.0178

0.048

0.092

0.2482*

0.0089

0.0098*

0.1343

0.0336* b, * c

ISDR

          

SVR

3.04

0.60

0.0253

0.061

0.1696

0.3096*

0.0269

0.0219*

0.151

0.0472*

NR

1.17

0.40

0.0098

0.051

0.0537

0.2766*

0.022

0.0174*

0.4457

0.0521*

ETR

2.01

0.13

0.0168

0.051

0.1335

0.2814*

0.0109

0.0111*

0.1485

0.0390*

NLS

          

SVR

0.58

0.10

0.0213

0.099

0.2658

0.4935*

0.0617

0.0598* a

0.4523

0.1143*

NR

0.20

0.03

0.0075

0.068

0.1399

0.2529*

0.0541

0.0555* a

0.3864

0.2166*

ETR

0.47

0.16

0.0173

0.063

0.2367

0.2102*

0.0557

0.0607

0.2663

0.2705*

V3

          

SVR

1.69

0.76

0.0258

0.081

0.1088

0.2344*

0.0406

0.0622* a

0.3415

0.1940* a

NR

0.91

0.55

0.0138

0.063

0.0594

0.1246*

0.0313

0.0664* a, * c

0.4752

0.4130* a, * c

ETR

1.37

0.83

0.0208

0.066

0.0868

0.1817*

0.0342

0.0488* c

0.4022

0.1996* c

  1. Values for number of mutations and for genetic distance, rates of synonymous substitution per synonymous site (dS), non-synonymous substitution per non-synonymous site (dN) and dN/dS ratio obtained by ws and bs analysis for each response group regarding the complete NS5A and the regions studied.
  2. * Significant difference among all groups; p < 0.05
  3. * aSignificant difference between SVR and NR; p < 0.05
  4. * b Significant difference between SVR and ETR; p < 0.05
  5. * c Significant difference between NR and ETR; p < 0.05