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Table 3 MIRU-VNTR genotypes of M. tuberculosis isolates from patients with multiple strain TB infections

From: Detection of multiple strains of Mycobacterium tuberculosis using MIRU-VNTR in patients with pulmonary tuberculosis in Kampala, Uganda

    MIRU-VNTR Locus amplified
PTID Time point Sample 580 960 1644 2996 3192 802 424 577 1955 2163 2165 2401 3690 4052 4156
A BL 35357 2,5 2 4,5 3,4,6 1,3,5 3,4,6   4 2,6 1,3 4 1,2 3 2,6 5
  BL 35358 2,5 2 4,5 4 1,3 4   4 2 1   1   2  
B BL 33007 2 5 1,3,4 4,6 4 4,6,7 5 2   1,2,3 3 2,3,5   4  
C BL 34347 2 5 1 3 2 4   5 4 2 2 2   3  
  BL 34348 2 5 1 3 2,3 3,4,5   5,4,3 2,3,4 2 2,3,4 2,3,4   3  
D BL 33914 2 4 4 4 2 3 4 3 3 2 4 4 4 2 3
  BL 33913 2 4 4 3 1 2   4 3 2 4 2   2 3
E BL 35584 2 2 3 3 3 4 2 4 3 2 3 2 2 3 8
  BL 35583 3 4 5 3 2 3 2 4 2 2 4 2 4 3 3
F BL 37768 2 1 1 2 1 2   4 2 2 2 2 2 3  
  BL 37767 2 5 1 3 1 3 4 5 2 1 2 2 2 3  
G BL 38228 2 7 3 6,8 5 4   2 2,3,4 4 3 6   4 9
H BL 33027 MOTT               
  BL 33026 MOTT               
  M2 33608 2' 5 3 6 4 6 5 2   2 3 3   4  
  M2 33609 2 5 3 4,6    5 2,3   2 3 2, 3   4  
  M2 33610 2' 5 1 6   4 5 2   2 3 3   4  
  1. The numerical figures (1 to 9) represent the number of alleles per amplified MIRU-VNTR loci, as described by Supply et al [19, 20]. Where there is more than one numerical figure per locus implies existence of more than one MTB strain in the sample, indicating multiple strain infection with M. tuberculosis (Patient samples A, B, C, and G). Serial samples from patients D, E, F, and H had different strains at different sampling points, which also indicate multiple strains infection. For patients A-G, blanks in copy numbers are presumed to be due to technical laboratory error. For patient H, blanks are likely due to MOTT co-infection.
  2. 2' is a standard copy number noted in the MIRU manual; PTID, Patient Identification; BL, Baseline sample collection; M2, sample collection in the second month; MOTT, Mycobcateria Other Than Tuberculosis