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Table 3 Results of neutralization test with different poliovirus type 1 challenge strains in adults immunized totally or partially with OPV.

From: Immunity status of adults and children against poliomyelitis virus type 1 strains CHAT and Sabin (LSc-2ab) in Germany

    Poliovirus Type 1
Strain CHAT
Poliovirus Type 1 Strain Sabin (LSc-2ab)
    ATTC
VR-1562
WHO reference virus Behringwerke AG DVV reference virus
Case No. Age Ratio* GMT* (IU/ml) GMT (IU/ml) GMT (IU/ml) GMT (IU/ml)
1 16   < 8 (< 1,1) 11 (0,6) 11 (0,8) 8 (0,8)
2 29   < 8 (< 1,1) 16 (0,8) 19 (1,5) 11 (1,1)
3 24   < 8 (< 1,1) 16 (0,8) 19 (1,5) 8 (0,8)
4 33   < 8 (< 1,1) 8 (0,4) 8 (0,6) < 8 (< 1,1)
5 29   < 8 (< 1,1) 32 (1,7) 53 (4,1) 32 (3,3)
6 49   < 8 (< 1,1) 32 (1,7) 19 (1,5) 16 (1,6)
7 42   < 8 (< 1,1) 45 (2,4) 45 (3,5) 64 (6,6)
8 43   < 8 (< 1,1) 16 (0,8) 11 (0,8) 11 (1,1)
9 50 8 8 (1,1) 64 (3,4) 16 (1,2) 32 (3,3)
10 53 11 8 (1,1) 90 (4,8) 53 (4,1) 32 (3,3)
11 10 11 16 (2,2) 181 (9,7) 256 (19,7) 181 (18,7)
12 37 10 17 (2,4) 181 (9,7) 76 (5,9) 128 (13,2)
13 40 17 28 (3,9) 512 (27,5) 362 (27,9) 256 (26,5)
14 31 8 32 (4,4) 256 (13,7) 152 (11,7) 256 (26,5)
15 40 32 32 (4,4) 1024 (55) 362 (27,9) 362 (37,5)
16 44 5 45 (6,2) 256 (13,7) 181 (13,9) 181 (18,7)
17 40 11 64 (8,8) 724 (38,9) 430 (33,1) 724 (75)
18 28 5 128 (17,7) 724 (38,9) 304 (23,4) 256 (26,5)
19 18 5 128 (17,7) 724 (38,9) 512 (39,4) 512 (53)
20 37 8 128 (17,7) 1024 (55) 861 (66,3) 512 (53)
21 49 8 128 (17,7) 1024 (55) 1024 (78,9 1024 (106,1)
22 41 4 8 (1,1) 32 (1,7) 32 (2,5) 22 (2,3)
23 43 4 8 (1,1) 32 (1,7) 26 (2,0) 22 (2,3)
24 25 1 16 (2,2) 16 (0,8) 22 (1,7) 16 (1,6)
25 59 4 16 (2,2) 64 (3,4) 38 (2,9) 32 (3,3)
26 54 1 32 (4,4) 32 (1,7) 26 (2,0) 16 (1,6)
27 64 2 32 (4,4) 64 (3,4) 53 (4,1) 22 (2,3)
28 46 1 35 (4,9) 64 (3,4) 64 (4,9) 64 (6,6)
29 60 1 64 (8,8) 90 (4,8) 76 (5,9) 90 (9,3)
30 29 2 64 (8,8) 181 (9,7) 181 (13,9) 64 (6,6)
31 60 2 128 (17,7) 256 (13,7) 215 (16,6) 181 (18,7)
32 46 2 128 (17,7) 256 (13,7) 152 (11,7) 128 (13,2)
33 36 2 128 (17,7) 362 (19,4) 256 (19,7) 256 (6,5)
34 24 2 256 (35,5) 512 (27,5) 512 (39,4) 512 (53)
35 28 4 256 (35,5) 1024 (55) 724 (55,8) 512 (53)
36 37 2 512 (71,1) 1024 (55) 1024 (78,9) 1024 (106,1)
37 58 2 512 (71,1) 1024 (55) 1024 (78,9) 724 (75)
38 35 1 1024 (142,3) 1024 (55) 724 (55,8) 1024 (106,1)
39 36 1 1024 (142,3) 1024 (55) 861 (66,3) 724 (75)
40 40 1 1024 (142,3) 1024 (55) 1024 (78,9) 1024 (106,1)
41 61 1 1024 (142,3) 1024 (55) 1024 (78,9) 1024 (106,1)
  1. The sera were grouped as follows:
  2. In sera No. 1 to 8 antibody titres against the strain CHAT were lower than 1: 8.
  3. In sera No. 9 to 21 antibodies titre against the strain CHAT were five or more fold lower than against the strain Sabin.
  4. In sera from No. 22 to 41 the difference between antibodies titre against the strain CHAT and the strain Sabin was fourfold and less.
  5. Case numbers in Tables 1 and 2 correspond to the case numbers in Table 3.
  6. *Ratio of titre against Sabin 1 WHO reference strain to titre against CHAT
  7. **GMT Reciprocal geometric mean titers