Table 3 Results of neutralization test with different poliovirus type 1 challenge strains in adults immunized totally or partially with OPV.
| Â | Â | Â | Poliovirus Type 1 Strain CHAT | Poliovirus Type 1 Strain Sabin (LSc-2ab) | ||
|---|---|---|---|---|---|---|
| Â | Â | Â | ATTC VR-1562 | WHO reference virus | Behringwerke AG | DVV reference virus |
Case No. | Age | Ratio* | GMT* (IU/ml) | GMT (IU/ml) | GMT (IU/ml) | GMT (IU/ml) |
1 | 16 | Â | < 8 (< 1,1) | 11 (0,6) | 11 (0,8) | 8 (0,8) |
2 | 29 | Â | < 8 (< 1,1) | 16 (0,8) | 19 (1,5) | 11 (1,1) |
3 | 24 | Â | < 8 (< 1,1) | 16 (0,8) | 19 (1,5) | 8 (0,8) |
4 | 33 | Â | < 8 (< 1,1) | 8 (0,4) | 8 (0,6) | < 8 (< 1,1) |
5 | 29 | Â | < 8 (< 1,1) | 32 (1,7) | 53 (4,1) | 32 (3,3) |
6 | 49 | Â | < 8 (< 1,1) | 32 (1,7) | 19 (1,5) | 16 (1,6) |
7 | 42 | Â | < 8 (< 1,1) | 45 (2,4) | 45 (3,5) | 64 (6,6) |
8 | 43 | Â | < 8 (< 1,1) | 16 (0,8) | 11 (0,8) | 11 (1,1) |
9 | 50 | 8 | 8 (1,1) | 64 (3,4) | 16 (1,2) | 32 (3,3) |
10 | 53 | 11 | 8 (1,1) | 90 (4,8) | 53 (4,1) | 32 (3,3) |
11 | 10 | 11 | 16 (2,2) | 181 (9,7) | 256 (19,7) | 181 (18,7) |
12 | 37 | 10 | 17 (2,4) | 181 (9,7) | 76 (5,9) | 128 (13,2) |
13 | 40 | 17 | 28 (3,9) | 512 (27,5) | 362 (27,9) | 256 (26,5) |
14 | 31 | 8 | 32 (4,4) | 256 (13,7) | 152 (11,7) | 256 (26,5) |
15 | 40 | 32 | 32 (4,4) | 1024 (55) | 362 (27,9) | 362 (37,5) |
16 | 44 | 5 | 45 (6,2) | 256 (13,7) | 181 (13,9) | 181 (18,7) |
17 | 40 | 11 | 64 (8,8) | 724 (38,9) | 430 (33,1) | 724 (75) |
18 | 28 | 5 | 128 (17,7) | 724 (38,9) | 304 (23,4) | 256 (26,5) |
19 | 18 | 5 | 128 (17,7) | 724 (38,9) | 512 (39,4) | 512 (53) |
20 | 37 | 8 | 128 (17,7) | 1024 (55) | 861 (66,3) | 512 (53) |
21 | 49 | 8 | 128 (17,7) | 1024 (55) | 1024 (78,9 | 1024 (106,1) |
22 | 41 | 4 | 8 (1,1) | 32 (1,7) | 32 (2,5) | 22 (2,3) |
23 | 43 | 4 | 8 (1,1) | 32 (1,7) | 26 (2,0) | 22 (2,3) |
24 | 25 | 1 | 16 (2,2) | 16 (0,8) | 22 (1,7) | 16 (1,6) |
25 | 59 | 4 | 16 (2,2) | 64 (3,4) | 38 (2,9) | 32 (3,3) |
26 | 54 | 1 | 32 (4,4) | 32 (1,7) | 26 (2,0) | 16 (1,6) |
27 | 64 | 2 | 32 (4,4) | 64 (3,4) | 53 (4,1) | 22 (2,3) |
28 | 46 | 1 | 35 (4,9) | 64 (3,4) | 64 (4,9) | 64 (6,6) |
29 | 60 | 1 | 64 (8,8) | 90 (4,8) | 76 (5,9) | 90 (9,3) |
30 | 29 | 2 | 64 (8,8) | 181 (9,7) | 181 (13,9) | 64 (6,6) |
31 | 60 | 2 | 128 (17,7) | 256 (13,7) | 215 (16,6) | 181 (18,7) |
32 | 46 | 2 | 128 (17,7) | 256 (13,7) | 152 (11,7) | 128 (13,2) |
33 | 36 | 2 | 128 (17,7) | 362 (19,4) | 256 (19,7) | 256 (6,5) |
34 | 24 | 2 | 256 (35,5) | 512 (27,5) | 512 (39,4) | 512 (53) |
35 | 28 | 4 | 256 (35,5) | 1024 (55) | 724 (55,8) | 512 (53) |
36 | 37 | 2 | 512 (71,1) | 1024 (55) | 1024 (78,9) | 1024 (106,1) |
37 | 58 | 2 | 512 (71,1) | 1024 (55) | 1024 (78,9) | 724 (75) |
38 | 35 | 1 | 1024 (142,3) | 1024 (55) | 724 (55,8) | 1024 (106,1) |
39 | 36 | 1 | 1024 (142,3) | 1024 (55) | 861 (66,3) | 724 (75) |
40 | 40 | 1 | 1024 (142,3) | 1024 (55) | 1024 (78,9) | 1024 (106,1) |
41 | 61 | 1 | 1024 (142,3) | 1024 (55) | 1024 (78,9) | 1024 (106,1) |