Seropositivity rates | GMT | SCR (Negative pre-vaccination HI titre and P/V HI titre ≥1:40, or proportion with ≥4-fold increase from pre- to post vaccination) | SCF (Mean GMT increase in titre >2.5 [adults]; >2.0 [aged over 60 y]) | SPR (% subjects with P/V HI titre ≥1:40) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Antibody | Group | D | N | n | % (95% CI) | Value (95% CI) | N | n | % (95% CI) | N | Value (95% CI) | N | n | % (95% CI) |
A/Indonesia | 20-40 Y | 0 | 50 | 0 | 0.0 (0.0-7.1) | 5.0 (5.0-5.0) | - | - | - | - | - | 50 | 0 | 0.0 (0.0-7.1) |
21 | 50 | 24 | 48.0 (33.7-62.6) | 15.8 (11.0-22.8) | 50 | 19 | 38.0 (24.7-52.8) | 50 | 3.2 (2.2-4.6) | 50 | 19 | 38.0 (24.7-52.8) | ||
42 | 50 | 45 | 90.0 (78.2-96.7) | 156.8 (105.8-232.3) | 50 | 45 | 90.0 (78.2-96.7) | 50 | 31.4 (21.2-46.5) | 50 | 45 | 90.0 (78.2-96.7) | ||
182 | 49 | 30 | 61.2 (46.2-74.8) | 25.6 (17.3-38.1) | 49 | 29 | 59.2 (44.2-73.0) | 49 | 5.1 (3.5-7.6) | 49 | 29 | 59.2 (44.2-73.0) | ||
41-64 Y | 0 | 50 | 5 | 10.0 (3.3-21.8) | 5.4 (5.0-5.8) | - | - | - | - | - | 50 | 0 | 0.0 (0.0-7.1) | |
21 | 50 | 27 | 54.0 (39.3-68.2) | 15.4 (10.7-22.0) | 50 | 16 | 32.0 (19.5-46.7) | 50 | 2.8 (2.0-4.0) | 50 | 16 | 32.0 (19.5-46.7) | ||
42 | 50 | 48 | 96.0 (86.3-99.5) | 142.1 (104.0-194.3) | 50 | 46 | 92.0 (80.8-97.8) | 50 | 26.2 (19.2-35.8) | 50 | 46 | 92.0 (80.8-97.8) | ||
182 | 50 | 40 | 80.0 (66.3-90.0) | 37.4 (27.5-50.8) | 50 | 38 | 76.0 (61.8-86.9) | 50 | 6.9 (5.1-9.2) | 50 | 38 | 76.0 (61.8-86.9) | ||
A/turkey/Turkey | 20-40 Y | 0 | 50 | 2 | 4.0 (0.5-13.7) | 5.7 (4.8-6.8) | - | - | - | - | - | 50 | 2 | 4.0 (0.5-13.7) |
21 | 50 | 13 | 26.0 (14.6-40.3) | 8.0 (6.1-10.4) | 50 | 3 | 6.0 (1.3-16.5) | 50 | 1.4 (1.1-1.8) | 50 | 5 | 10.0 (3.3-21.8) | ||
42 | 50 | 30 | 60.0 (45.2-73.6) | 24.8 (16.6-37.1) | 50 | 27 | 54.0 (39.3-68.2) | 50 | 4.4 (3.0-6.5) | 50 | 29 | 58.0 (43.2-71.8) | ||
182 | 49 | 30 | 61.2 (46.2-74.8) | 19.2 (13.4-27.3) | 49 | 18 | 36.7 (23.4-51.7) | 49 | 3.4 (2.4-4.7) | 49 | 20 | 40.8 (27.0-55.8) | ||
41-64 Y | 0 | 50 | 2 | 4.0 (0.5-13.7) | 5.2 (4.9-5.5) | - | - | - | - | - | 50 | 0 | 0.0 (0.0-7.1) | |
21 | 50 | 18 | 36.0 (22.9-50.8) | 9.6 (7.3-12.5) | 50 | 7 | 14.0 (5.8-26.7) | 50 | 1.8 (1.4-2.4) | 50 | 8 | 16.0 (7.2-29.1) | ||
42 | 50 | 31 | 62.0 (47.2-75.3) | 24.0 (16.1-35.6) | 50 | 27 | 54.0 (39.3-68.2) | 50 | 4.6 (3.1-6.8) | 50 | 27 | 54.0 (39.3-68.2) | ||
182 | 50 | 38 | 76.0 (61.8-86.9) | 30.7 (22.2-42.5) | 50 | 30 | 60.0 (45.2-73.6) | 50 | 5.9 (4.2-8.2) | 50 | 30 | 60.0 (45.2-73.6) | ||
A/Vietnam | 20-40 Y | 0 | 50 | 1 | 2.0 (0.1-10.6) | 5.2 (4.8-5.7) | - | - | - | - | - | 50 | 1 | 2.0 (0.1-10.6) |
21 | 50 | 5 | 10.0 (3.3-21.8) | 5.7 (5.0-6.5) | 50 | 0 | 0 (0-7.1) | 50 | 1.1 (1.0-1.2) | 50 | 1 | 2.0 (0.1-10.6) | ||
42 | 50 | 26 | 52.0 (37.4-66.3) | 12.7 (9.5-17.1) | 50 | 14 | 28.0 (16.2-42.5) | 50 | 2.4 (1.8-3.2) | 50 | 15 | 30.0 (17.9-44.6) | ||
182 | 49 | 17 | 34.7 (21.7-49.6) | 8.6 (6.8-10.8) | 49 | 2 | 4.1 (0.5-14.0) | 49 | 1.6 (1.3-2.1) | 49 | 3 | 6.1 (1.3-16.9) | ||
41-64 Y | 0 | 50 | 5 | 10.0 (3.3-21.8) | 5.9 (5.0-6.8) | - | - | - | - | - | 50 | 2 | 4.0 (0.5-13.7) | |
21 | 50 | 13 | 26.0 (14.6-40.3) | 7.0 (5.8-8.5) | 50 | 1 | 2.0 (0.1-10.6) | 50 | 1.2 (1.1-1.4) | 50 | 4 | 8.0 (2.2-19.2) | ||
42 | 50 | 24 | 48.0 (33.7-62.6) | 13.3 (9.7-18.2) | 50 | 12 | 24.0 (13.1-38.2) | 50 | 2.3 (1.7-3.0) | 50 | 15 | 30.0 (17.9-44.6) | ||
182 | 50 | 23 | 46.0 (31.8-60.7) | 10.7 (8.2-13.9) | 50 | 10 | 20.0 (10.0-33.7) | 50 | 1.8 (1.4-2.4) | 50 | 12 | 24.0 (13.1-38.2) |