|  | Serotype Distribution (%) |  | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Region | Patients | Ia | Ib | II | III | IV | V | VI | VII | VIII | NT | Â |
Madigan | 207 | 59 | 25 | 25 | 56 | 4 | 35 | 2 | 0 | 0 | 1 | #patients |
 |  | 28.50 | 12.08 | 12.08 | 27.05 | 1.93 | 16.91 | 0.97 | 0.00 | 0.00 | 0.48 | % |
Canada | 353 | 77 | 35 | 40 | 66 | 5 | 78 | Â | Â | 1 | 49 | #patients |
 |  | 21.81 | 9.92 | 11.33 | 18.70 | 1.42 | 22.10 | 0.00 | 0.00 | 0.28 | 13.88 | % |
 |  | 0.104 | 0.512 | 0.906 | 0.027 | 0.918 | 0.171 |  |  |  | 0.001 | p-value |
US | 7609 | 2039 | 618 | 826 | 1887 | 73 | 1139 | 26 | 3 | 17 | 869 | #patients |
 |  | 26.80 | 8.12 | 10.86 | 24.80 | 0.96 | 14.97 | 0.34 | 0.04 | 0.22 | 11.42 | % |
 |  | 0.642 | 0.055 | 0.658 | 0.511 | 0.299 | 0.501 | 0.364 |  |  | 0.001 | p-value |
Europe | 2662 | 485 | 329 | 384 | 747 | 98 | 396 | 16 | 16 | 15 | 131 | #patients |
 |  | 18.22 | 12.36 | 14.43 | 28.06 | 3.68 | 14.88 | 0.60 | 0.60 | 0.56 | 4.92 | % |
 |  | 0.001 | 0.93 | 0.407 | 0.817 | 0.265 | 0.492 | 0.847 |  |  | 0.006 | p-value |
ME, EEu | 566 | 78 | 24 | 76 | 82 | 17 | 79 | 10 | 7 | 0 | 41 | #patients |
 |  | 13.78 | 4.24 | 13.43 | 14.49 | 3.00 | 13.96 | 1.77 | 1.24 | 0.00 | 7.24 | % |
 |  | 0.001 | 0.001 | 0.709 | 0.001 | 0.575 | 0.363 | 0.64 |  |  | 0.001 | p-value |
Asia | 1521 | 171 | 214 | 132 | 446 | 25 | 266 | 81 | 22 | 48 | 85 | #patients |
 |  | 11.24 | 14.07 | 8.68 | 29.32 | 1.64 | 17.49 | 5.33 | 1.45 | 3.16 | 5.59 | % |
 |  | 0.001 | 0.502 | 0.142 | 0.553 | 0.987 | 0.913 | 0.01 |  |  | 0.003 | p-value |
Africa | 260 | 37 | 12 | 22 | 89 | 10 | 82 | 0 | 0 | 0 | 7 | #patients |
 |  | 14.23 | 4.62 | 8.46 | 34.23 | 3.85 | 31.54 | 0.00 | 0.00 | 0.00 | 2.69 | % |
 |  | 0.001 | 0.005 | 0.256 | 0.118 | 0.349 | 0.001 |  |  |  | 0.142 | p-value |
S. Am | 113 | 23 | 12 | 28 | 13 | 2 | 6 | Â | Â | Â | 10 | #patients |
 |  | 20.35 | 10.62 | 24.78 | 11.50 | 1.77 | 5.31 | 0.00 | 0.00 | 0.00 | 8.85 | % |
 |  | 0.144 | 0.836 | 0.006 | 0.002 | 0.749 | 0.005 |  |  |  | 0.001 | p-value |
Mexico | 492 | 277 | Â | 112 | 88 | Â | Â | Â | Â | Â | 16 | #patients |
 |  | 56.30 | 0.00 | 22.76 | 17.89 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.25 | % |
 |  | 0.001 |  | 0.002 | 0.009 |  |  |  |  |  | 0.057 | p-value |
Aus, NZ | 125 | 25 | 24 | 5 | 26 | 4 | 37 | 0 | Â | 0 | 2 | #patients |
 |  | 20.00 | 19.20 | 4.00 | 20.80 | 3.20 | 29.60 | 0.00 | 0.00 | 0.00 | 1.60 | % |
 |  | 0.111 | 0.107 | 0.022 | 0.251 | 0.728 | 0.01 |  |  |  | 0.655 | p-value |