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Table 1 Admission characteristics for children in the two cohorts

From: Hypoglycaemia in severe malaria, clinical associations and relationship to quinine dosage

Clinical features Quinine 15 mg/kg (N = 954) n (%) Quinine 20 mg/kg (N = 283) n (%) P-value Ŧ
Coma (BCS ≤ 2) 434/953 (46) 123/279 (44) 0.67
Deep breathing 391/953 (41) 95/277 (34) 0.04
Impaired consciousness 706/953 (74) 204/279 (73) 0.91
Severe anaemia (Hb < 5 g/dl) 229/949 (24) 47/279 (17) 0.01
Temperature gradient 263/951 (28) 55/277 (20) 0.009
Delayed capillary refill (> 2 seconds) 232/953 (24) 41/279 (15) 0.001
Weak Pulse volume 159/953 (17) 31/277 (11) 0.03
Mid Upper Arm Circumference < 12 cm 59/914 (6) 9/240 (4) 0.11
Visible wasting 58/953 (6) 6/277 (2) 0.01
Seizures 168/953 (18) 38/277 (14) 0.13
Prostration 436/953 (46) 104/279 (37) 0.05
Hypoglycaemia < = 3 mmol/l 155/952 (16) 26/282 (9) 0.003
Severe hypoglycaemia(< 2.2 mmol/l) 118/952 (12) 19/282 (7) 0.008
Creatinine > 80 mmol/l 225/904 (25) 49/211 (23) 0.61
Potassium > 5 mmol/l 149/934 (16) 17/259 (7) < 0.01
Mean laboratory variable [SD]
Haemoglobin level, mg/dl 7.06 [2.63] 7.53 [2.44] 0.004
pH 7.28 [0.14] 7.30 [0.51] 0.34
pCO2,mmol/L 4.17 [1.92] 3.98 [1.73] 0.18
Base Deficit, mmol/L 9.99 [6.63] 8.49 [5.72] 0.002
Sodium level, mmol/l 134.33 [5.62] 133.39 [5.51] 0.02
Creatinine level, mmol/l 68.89[41.7] 66.81 [32.65] 0.49
Parasitaemia ×103parasites/μl 3651 [3149 - 4234] 5604 [4393 - 7150] 0.01
  1. IQR - Inter-quartile range, SE-Standard error, Ŧ Test statistic - χ2 test or t-test on means