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Figure 5 | BMC Infectious Diseases

Figure 5

From: Spiral ligament fibrocyte-derived MCP-1/CCL2 contributes to inner ear inflammation secondary to nontypeable H. influenzae-induced otitis media

Figure 5

Requirement of CCR2 for migration of monocytes in response to NTHI-induced SLF-derived molecules. Migration assays show that the CCR2 inhibitor (RS 102895) markedly inhibits migration of THP-1 cells attracted by NTHI-induced SLF-derived molecules, in a dose-dependent manner (A). Giemsa staining of the migrated splenocytes shows that CCR2 deficiency inhibits migration of monocyte-like cells in response to the NTHI-induced SLF-derived molecules (B).

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