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Table 4 Predictive values of the cirrhosis algorithm and of liver biopsy, FibroScan and FibroTest for the prediction of HCV-related severe events occurrence, ANRS CO 13 HEPAVIH cohort of HIV-HCV co-infected patients

From: The French national prospective cohort of patients co-infected with HIV and HCV (ANRS CO13 HEPAVIH): Early findings, 2006-2010

   HCV-related severe eventsa   
   Absence (n) Presence (n) PPV (%) NPV (%)
Algorithm* N=987 Absence of cirrhosis 752 4 12.5 99.5
  Presence of cirrhosis 203 29   
Liver Biopsy N=192 Metavir < F4 161 2 10.3 98.8
  Metavir F4 26 3   
FibroScan N=806 <12.5KPa 653 4 7.4 99.4
  ≤ 12.5 KPa 138 11   
FibroTest N=718 Metavir < F4 528 7 8.2 98.7
  Metavir F4 168 15   
  1. * See definition in Methods section; PPV: positive predictive value; NPV negative predictive value
  2. a HCV-related severe events: ascites, varices bleeding, hepatic encephalopathy, hepatocellular carcinoma or HCV-related death