Figure 1

Cd36 ^-/- mice have lower bacillary burden relative to Cd36 ^+/+ controls after challenge with M. bovis BCG. A. Intraperitoneal infection (day 0) with BCG (1.5×10⁷ organisms) resulted in a rise in mycobacterial counts in the spleens of Cd36 ^+/+(wild type) mice to a maximum at day 14 with subsequent decline. The mycobacterial counts in Cd36 ^-/- mice (white box, dashed line) were lower overall (p < 0.001), and at specific time points (day 7, *p < 0.01; day 14, *p < 0.001). B and C. Differences between genotypes were less pronounced in the liver (B) and lung (C). Results are displayed as mean ± SEM, with 8 mice per group at each time point, representing two pooled independent experiments.