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Table 3 Seroprotection rates and GMCs for diphtheria, tetanus, HBV and pertussis before dose 1 (pre) and one month post-dose 3 (post; ATP cohort for immunogenicity)

From: The immunogenicity and safety of a reduced PRP-content DTPw-HBV/Hib vaccine when administered according to the accelerated EPI schedule

   Seroprotection rates/Vaccine response rates GMC
   DTPw-HBV/Hib 2.5 [Kft] DTPw-HBV/Hib DTPw -HBV/Hib2.5 DTPw-HBV/Hib 2.5 [Kft] DTPw-HBV/Hib DTPw -HBV/Hib2.5
  Time point N % 95% CI N % 95% CI N % 95% CI Value 95% CI Value 95% CI Value 95% CI
Diphtheria ≥0.1 IU/ml (or ≥0.016 IU/ml by neutralization assay) Pre 93 31.2 22.0-41.6 89 34.8 25.0-45.7 85 24.7 16.0-35.3 0.086 0.070-0.105 0.082 0.069-0.097 0.076 0.063-0.093
  Post 93 100 96.1-100 89 98.9 95.9-100 85 100 95.8-100 2.89 2.30-3.64 1.76 1.41-2.19 1.65 1.36-2.02
Tetanus ≥0.1 IU/ml Pre 93 100 96.1-100 89 100 95.9-100 85 100 95.8-100 1.950 1.561-2.437 2.416 1.991-2.932 2.112 1.751-2.548
  Post 93 100 96.1-100 89 100 95.9-100 85 100 95.8-100 4.74 3.78-5.95 2.82 2.32-3.45 2.77 2.24-3.44
HBV ≥10 mIU/ml Pre 85 25.9 17.0-36.5 85 24.7 16.0-35.3 84 21.4 13.2-31.7 8.3 6.7-10.3 8.0 6.5-9.8 6.6 5.8-7.5
  Post 92 100 96.1-100 89 100 95.9-100 85 100 95.8-100 781.1 629.7-968.8 598.2 477.7-749.1 695.3 542.1-891.7
Anti-BPT antibodies ≥15 El.U/ml Pre 93 16.1 9.3-25.2 89 19.1 11.5-28.8 85 22.4 14.0-32.7 9.1 8.2-10.1 9.1 8.3-10.0 9.8 8.7-11.0
  Post 93 98.9 94.2-100 89 98.9 93.9-100 85 100 95.8-100 63.4 55.4-72.7 83.7 73.6-95.2 100.3 88.4-113.7
VR for anti-BPT antibody Post 93 97.8 92.4-99.7 89 98.9 93.9-100 85 98.8 93.6-100       
  1. BPT = Bordetella pertussis; CI = confidence interval; GMC = geometric mean concentration; HBV = hepatitis B vaccine; IU = international unit; N = number of subjects with available results; VR = vaccine response.