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Table 3 Levels of HMGB1, LBP, IL-6 and CRP in infected children without SIRS, with sepsis and with severe sepsis.

From: High-mobility group box-1 protein, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in children with community acquired infections and bacteraemia: a prospective study

Biomarker Infected patients without SIRS
(n = 36)
Sepsis patients
(n = 91)
Severe sepsis patients
(n = 13)
p-valuea
HMGB1 (ng/ml)     
Median 2.5 3.0 3.1 NS
IQR 0.3-5.9 1.0-7.3 1.3-14.3  
p-valueb   NS NS  
Lipopolysaccharide--binding protein (μg/ml)     
Median 14.7 26.4 79.7 < 0.001
IQR 8.7-26.0 17.5-42.2 57.8-90.6  
p-value   < 0.001 < 0.001  
Interleukin 6 (pg/ml)     
Median 8.9 32.1 290.0 < 0.001
IQR 4.0--18.8 13.8-68.1 67.9-522.6  
p-valueb   < 0.001 < 0.001  
C-reactive protein (mg/l)     
Median 12.0 63.0 211.8 < 0.001
IQR 3.1-36.6 27.0-114.5 108.0-318.6  
p-valueb   < 0.001 < 0.001  
  1. Data presented as median and interquartile range (IQR). SIRS, systemic inflammatory response syndrome. HMGB1, high mobility box-1 protein; LBP, lipopolysaccharide-binding proteine; IL-6, interleukine-6; CRP, C-reactive protein. NS, not significant. aKruskal-Wallis tests. b Mann Whitney two independent sample tests, compared with the previous group in the table.