High-mobility group box-1 protein, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in children with community acquired infections and bacteraemia: a prospective study

Table 3 Levels of HMGB1, LBP, IL-6 and CRP in infected children without SIRS, with sepsis and with severe sepsis.

Biomarker	Infected patients without SIRS (n = 36)	Sepsis patients (n = 91)	Severe sepsis patients (n = 13)	p-value^a
HMGB1 (ng/ml)
Median	2.5	3.0	3.1	NS
IQR	0.3-5.9	1.0-7.3	1.3-14.3
p-value^b		NS	NS
Lipopolysaccharide--binding protein (μg/ml)
Median	14.7	26.4	79.7	< 0.001
IQR	8.7-26.0	17.5-42.2	57.8-90.6
p-value		< 0.001	< 0.001
Interleukin 6 (pg/ml)
Median	8.9	32.1	290.0	< 0.001
IQR	4.0--18.8	13.8-68.1	67.9-522.6
p-value^b		< 0.001	< 0.001
C-reactive protein (mg/l)
Median	12.0	63.0	211.8	< 0.001
IQR	3.1-36.6	27.0-114.5	108.0-318.6
p-value^b		< 0.001	< 0.001

Data presented as median and interquartile range (IQR). SIRS, systemic inflammatory response syndrome. HMGB1, high mobility box-1 protein; LBP, lipopolysaccharide-binding proteine; IL-6, interleukine-6; CRP, C-reactive protein. NS, not significant. ^aKruskal-Wallis tests. ^b Mann Whitney two independent sample tests, compared with the previous group in the table.

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