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Table 3 Seroreactivity of recombinant proteins in sera from TB patients, LTBI and HC

From: Rv1985c, a promising novel antigen for diagnosis of tuberculosis infection from BCG-vaccinated controls

 

TB (n = 117)

LTBI (n = 45)

HC (n = 67)

Antigens

No. Positive1

Sensitivity2 (%)

No. Positive1

Sensitivity3 (%)

No. Positive1

Specificity4 (%)

PATHOZYME-MYCO IgG

40

34.2

NT

NT

1

98.5

Rv1985c IgG

61

52.1 5

28

62.2%

2

97.0

Rv1985c IgM

23

19.7

5

11.1%

2

97.0

Rv1985c IgG + IgM

73

62.4 5

29

64.4%

3

95.5

Rv1985c+ PATHOZYME-MYCO IgG

82

70.1 5

NT

NT

3

95.5

  1. 1: For 1985c positive sera, defined as cases for which the optical density (OD) generated by the serum was greater than the mean OD of the healthy control sera plus two standard deviations. For PATHOZYME-MYCO IgG positive sera, defined as cases of more than 400 units per ml, which was calculated by extrapolating the OD from the standard curve and multiplying by 100;
  2. 2: Percentage of responding patients out of all TB patients tested;
  3. 3: Percentage of responding patients out of all LTBI tested;
  4. 4: Percentage of true-negative healthy controls out of all healthy control individuals tested;
  5. 5: Statistical significance was determined in respect to sensitivity of PATHOZYME-MYCO IgG by McNemar chi-square test, p < 0.01;
  6. NT: not tested.
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BMC Infectious Diseases

ISSN: 1471-2334

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