Group | Advanced liver diseases | TotalΔ | p-value | ||||
---|---|---|---|---|---|---|---|
Diagnosis | ASC | CH | HCC | ||||
Patient (No.) | 13 | 75 | 14 | 44 | 11 | 157 | - |
Gender (Male/Female) | 4/9 | 56/18 | 12/2 | 34/10 | 10/1 | 116/40 | 0.006 b |
Age (years, Mean ± SD) | 28 ± 9 | 35 ± 12 | 37 ± 9 | 47 ± 11 | 51 ± 6 | 38 ± 13 | < 0.0001* |
HBV DNA titer (lg, Mean ± SD) | 6 ± 2 | 7 ± 2 | 7 ± 1 | 7 ± 1 | 6 ± 1 | 7 ± 1 | 0.317* |
ALT (U/L, Mean ± SD) | 26 ± 24 | 255 ± 343 | 212 ± 199 | 107 ± 127 | 123 ± 151 | 184 ± 273 | 0.006* |
AST (U/L, Mean ± SD) | 33 ± 16 | 124 ± 187 | 136 ± 181 | 99 ± 104 | 162 ± 156 | 114 ± 161 | 0.237* |
nt 1753 (m/wt) | 0/13 | 8/67 | 2/12 | 12/32 | 3/8 | 25/132 | 0.053b |
nt 1762 (m/wt) | 1/12 | 51/24 | 14/0 | 32/12 | 10/1 | 108/49 | < 0.0001 b |
nt 1764 (m/wt) | 1/12 | 51/24 | 13/1 | 38/6 | 9/2 | 112/45 | < 0.0001 b |
nt 1776 (m/wt) | 0/13 | 3/72 | 0/14 | 5/39 | 0/11 | 8/149 | 0.214b |
nt 1803 (m/wt) | 0/13 | 2/73 | 0/14 | 6/38 | 1/10 | 9/148 | 0.082b |
nt 1846 (m/wt) | 0/13 | 9/66 | 1/13 | 6/38 | 2/9 | 18/139 | 0.617b |
nt 1896 (m/wt) | 0/13 | 17/58 | 7/7 | 13/31 | 6/5 | 43/114 | 0.009 b |
Mutations≥3 (Y/N)@ | 0/13 | 26/49 | 10/4 | 24/20 | 6/5 | 66/91 | 0.001 b |