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Table 1 Independent predictors of hearing loss after bacterial meningitis.

From: Simulated effect of pneumococcal vaccination in the Netherlands on existing rules constructed in a non-vaccinated cohort predicting sequelae after bacterial meningitis

Variable

Regression coefficient

Odds ratio (95% CI)

Contribution to risk score

Duration of symptoms

   

< 1 day

RC

 

0

1-2 days

0.8

2.3 (0.7-7.2)

10

> 2 days

1.0

2.8 (1.0-8.0)

13

Absence of petechiae

2.4

11.0 (2.7-45.4)

29

CSF glucose level < 0.6 mmol/L

1.0

2.8(1.2-6.6)

13

S. Pneumoniae

1.1

3.2 (1.2-8.5)

14

(Transient) ataxia

3.3

28.4 (5.7-142.3)

40

  1. Risk score = 10 × duration of symptoms 1-2 days + 13 × duration of symptoms > days + 29 × absence of petechiae + 13 × CSF glucose leven < 0.6 mmol/L + 14 × S. Pneumoniae + 40 × (transient) ataxia
  2. AUC of the regression model:: 0.87 (95% confidence interval 0.82-0.93)
  3. RC = reference category. For final risk score add all separate risk factors per child.
  4. RC = reference category; CSF = Cerebrospinal fluid.