Figure 4

Stochastic simulations. Effects of different second line drug treatment regimes on the frequency of patients colonized with bacteria and the fraction colonize with bacteria that are resistant to the first line drug. Mean fractions for 200 runs after 1 year under that treatment regime. (a, b) No input of patients with resistant bacteria. (c,d) 10% of the patients entering the hospital carry bacteria resistant to the first-line antibiotic. Save for those related to switching, the values of the parameters of these simulations are the same as those in Figures 2 and 3. The standard errors were less than 1% of the mean for all sets of parameters.