Skip to main content
Figure 2 | BMC Infectious Diseases

Figure 2

From: Antibiotic control of antibiotic resistance in hospitals: a simulation study

Figure 2

Deterministic model, numerical solutions: Change in the number of colonized patients or the frequency of resistance for different treatment regimes. (a) Change in the equilibrium frequency of patients colonized with susceptible bacteria for different frequencies of treatment with antibiotic 1. No resistance, and of the patients entering the hospital 60% are uncolonized and 40% are colonized with bacteria susceptible to antibiotic 1. The different curves correspond to different treatment rates which are in parentheses. Clearance rates with and without treatment are × = 0.10, v = 0.50, respectively, all colonized patients leave at the same rate, cS = cR = 0.10, and uncolonized patients leave the hospital at twice that rate, cU = 0.20. (b) Change in the number of patients colonized with bacteria resistant to antibiotic 1 with different frequencies of treatment with antibiotic 1. Parameters are the same as those in (a) but at the start of the simulation 10% of the patients in the hospital are colonized with resistant bacteria. (c) Change in the number of patients colonized with bacteria resistant to antibiotic 1 with different rates of switching to antibiotic 2. 40% of colonized patients are treated with antibiotic 1, fs = fr = 0.40 and antibiotic 1 and antibiotic 2 are equally effective on bacteria that are susceptible to their action. No input of resistant bacteria. Other parameters are the same as in previous figures. (d) Change in the number of patients colonized with bacteria resistant to antibiotic 1 with different rates of switching to antibiotic 2. 10% of the patients entering the hospital carry bacteria resistant to antibiotic 1, 40% are colonized with bacteria that are susceptible to antibiotic 1, and 50% are uncolonized. Other parameters are the same as in (c).

Back to article page