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Table 4 Sensitivity of AFB and multiplex-PCR as diagnostic tools in detecting paucibacillary as well as multibacillary leprosy cases among different categories of paucibacillary patients

From: Multiplex PCR technique could be an alternative approach for early detection of leprosy among close contacts - a pilot study from India

Clinical status of the disease Cases confirmed by AFB In SSS(Slit skin smear) Cases confirmed by Multiplex-PCR Percent of positivity by AFB test Percent of positivity of M-PCR test
  BI No of case    
Patients without treatment (New Cases)(n = 128) 0 85 62 (72.9%) 50.58% 82%
  1 43 43   
Patients on treatment not more than 2 months (n = 7) 0 6 3 (50%) 14.28% 57.14%
  1 1 1   
Patients released from treatment (RFT)(a)/later developed a new active lesion/relapsed cases(b) (n = 3) 0 3a 1a (33.3%) 0% 33.33%
  1 0 0   
Patients complaining of hypoesthesia but showing no clinical symptoms of leprosy - considered as Indeterminate type(n = 2) 0 2 1 (50%) 0% 50%
  1 0 0   
Total n = 140     31.4% (44/140) 79.2% (111/140)
BT n = 94
Clinical status of the disease Cases confirmed by AFB In SSS(Slit skin smear) Cases confirmed by Multiplex-PCR Percent of positivity by AFB test Percent of positivity of M-PCR test
  BI No of case    
Patients without treatment (New Cases)(n = 85) 0 68 55 (80.8%) 20% 84.70%
  1 17 17   
Patients on treatment not more than 2 months (n = 6) 0 5 2(40%) 16.6% 50%
  1 1 1   
Patients released from treatment (RFT)(a)/later developed a new active lesion/relapsed cases(b) (n = 3) 0 2a, 1b 1a,1b (33.33%) 0% 66.6%
  1 0 0   
Total n = 94     19.14% (18/94) 81.9% (77/94)
  1. TT (including 2 indeterminates) n = 138 + 2 Indeterminate