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Table 4 Sensitivity of AFB and multiplex-PCR as diagnostic tools in detecting paucibacillary as well as multibacillary leprosy cases among different categories of paucibacillary patients

From: Multiplex PCR technique could be an alternative approach for early detection of leprosy among close contacts - a pilot study from India

Clinical status of the disease

Cases confirmed by AFB In SSS(Slit skin smear)

Cases confirmed by Multiplex-PCR

Percent of positivity by AFB test

Percent of positivity of M-PCR test

 

BI

No of case

   

Patients without treatment (New Cases)(n = 128)

0

85

62 (72.9%)

50.58%

82%

 

1

43

43

  

Patients on treatment not more than 2 months (n = 7)

0

6

3 (50%)

14.28%

57.14%

 

1

1

1

  

Patients released from treatment (RFT)(a)/later developed a new active lesion/relapsed cases(b) (n = 3)

0

3a

1a (33.3%)

0%

33.33%

 

1

0

0

  

Patients complaining of hypoesthesia but showing no clinical symptoms of leprosy - considered as Indeterminate type(n = 2)

0

2

1 (50%)

0%

50%

 

1

0

0

  

Total n = 140

   

31.4% (44/140)

79.2% (111/140)

BT n = 94

Clinical status of the disease

Cases confirmed by AFB In SSS(Slit skin smear)

Cases confirmed by Multiplex-PCR

Percent of positivity by AFB test

Percent of positivity of M-PCR test

 

BI

No of case

   

Patients without treatment (New Cases)(n = 85)

0

68

55 (80.8%)

20%

84.70%

 

1

17

17

  

Patients on treatment not more than 2 months (n = 6)

0

5

2(40%)

16.6%

50%

 

1

1

1

  

Patients released from treatment (RFT)(a)/later developed a new active lesion/relapsed cases(b) (n = 3)

0

2a, 1b

1a,1b (33.33%)

0%

66.6%

 

1

0

0

  

Total n = 94

   

19.14% (18/94)

81.9% (77/94)

  1. TT (including 2 indeterminates) n = 138 + 2 Indeterminate