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Table 1 Model parameters, together with baseline value and range if varied during analysis.

From: Contingency planning for a deliberate release of smallpox in Great Britain - the role of geographical scale and contact structure

Parameter

Description

Value (Range)

Refs

g E

Rate of transition from latent to prodromal

1/12 days-1

[14]

g P

Rate of transition from prodromal to infectious

1/2.5 days-1

[15]

g I

Rate of transition from infectious to removed

1/8.6 days-1

[16]

δ

Case fatality risk

30%

[23, 33]

θ

Probability of case isolation success

90%

[21]

g Q

Rate of transition from isolated to removed

1/20 days-1

[5]

ϵ

Probability of contact tracing success

80%

[5]

ϵ1

Vaccine efficacy when susceptible

97.5%

[14]

ϵ2

Vaccine efficacy when latent

30%

[23]

g O

Rate of transition from observed to removed or vaccinated

1/15 days-1

[5]

γ

Proportion of population contraindicated for mass vaccination

30%

[25]

E 0

Number of index cases

10

see text

Number of index cases for secondary outbreak

1

see text

I trig

Number of clinical cases prior to detection

4

see text

Number of clinical cases prior to detection for secondary outbreak

1

see text

δ V

Vaccine fatality risk

10-5(0 -- 10-5)

[24]

R 0

Basic reproductive ratio

5 (3 -- 7)

[14]

R P

Prodromal type reproductive ratio

0.5 (0.1 -- 1.5)

[15, 17]

κ

Movement reductions when infectious

0.9 (0 -- 1)

[5]

v

Rate of mass vaccination

N/7 (see Figure 3(c))

see text

N

Population size of region

105(see Figure 3(a))

[28, 29]

ξ

Region outwardness

0.4 (see Figure 3(d))

[27, 30]

M

Number of regions of same type as outbreak region

n/a (see Figure 3(a))

[28, 29]

M 0

Number of regions at relevant scale initially infected

1 (1 -- 10)

see text

n

Neighbourhood size (contacts per individual)

17 (5 -- 50)

[18, 19]

Ï•

Clustering coefficient

0 (0 -- 0.5)

see text

  1. Either references are given, or the parameter value is discussed in the main text. Values referenced to [5] are typically also based on expert opinion from discussions with the Department of Health. [34] provides an example of the considerations involved in estimating these values