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Table 3 Diagnostic accuracy of hyaluronic acid (HA) measurement for significant fibrosis (F≥2), advanced fibrosis (F≥3) and cirrhosis (F4) in our cohort.

From: Can serum hyaluronic acid replace simple non-invasive indexes to predict liver fibrosis in HIV/Hepatitis C coinfected patients?

Cut-off TP FP TN FN (*)Se
(95% CI)
(*)Sp
(95% CI)
(*)PPV
(95% CI)
(*)NPV
(95% CI)
LR+
(95% CI)
LR-
(95% CI)
DOR
(95% CI)
Significant fibrosis (F≥ 2)
430 (ng/mL) 111 71 13 6 94.9
(90.4 - 99.3)
15.5
(7.1 - 23.8)
61.0
(53.6 - 68.7)
68.4
(44.9 - 91.9)
1.12
(1.01 - 1.24)
0.33
(0.14 - 0.78)
3.39
(1.23 - 9.32)
1250 (ng/mL) 67 23 61 50 57.3
(47.9 - 66.7)
72.6
(62.5 - 82.7)
74.4
(64.9 - 84.0)
55.0
(45.2 - 64.7)
2.09
(1.43 - 3.06)
0.59
(0.46 - 0.75)
3.55
(1.9 - 6.5)
1800 (ng/mL) 36 4 80 81 30.8
(21.9 - 39.6)
95.2
(90.1 - 100)
90.0
(79.5 -100)
49.7
(41.7 - 57.7)
6.46
(2.39 - 17.46)
0.73
(0.63 - 0.84)
8.89
(3.02 - 26.13)
Advanced fibrosis (F≥ 3)
687 (ng/mL) 61 88 49 3 95.3
(89.3 - 100)
35.8
(27.4 - 44.2)
40.9
(32.7 - 49.2)
94.2
(86.9 - 100)
1.48
(1.29 - 1.70)
0.13
(0.04 - 0.40)
11.32
(3.37 - 37.99)
1250 (ng/mL) 47 43 94 17 73.4
(61.8 - 85.0)
68.6
(60.5 - 76.7)
52.2
(41.3 - 63.1)
84.7
(77.5 - 91.8)
2.34
(1.75 - 3.12)
0.39
(0.25 - 0.6)
6.04
(3.1 - 11.7)
2290 (ng/mL) 18 7 130 46 28.1
(16.3 - 39.9)
94.9
(90.8 - 98.9)
72.0
(52.4 - 91.6)
73.9
(67.1 - 80.6)
5.50
(2.42 - 12.51)
0.76
(0.63 - 0.91)
7.27
(2.85 - 18.52)
Cirrhosis (F4)
1182 (ng/mL) 22 78 100 1 95.7
(85.1 - 100)
56.2
(48.6 - 63.7)
22.0
(13.4 - 30.6)
99.0
(96.6 - 100)
2.18
(1.81 - 2.63)
0.08
(0.01 - 0.53)
28.21
(3.72 - 213.86)
1320 (ng/mL) 21 63 115 2 91.3
(77.6 - 100)
64.6
(57.3 - 71.9)
25.0
(17.1 - 34.9)
98.3
(95.5 - 100)
2.58
(2.04 - 3.26)
0.13
(0.04 - 0.51)
19.17
(4.4 - 84.4)
2400 (ng/mL) 11 9 169 12 47.8
(25.2 - 70.4)
94.9
(91.4 - 98.4)
55.0
(30.7 - 79.3)
93.4
(89.5 - 97.3)
9.46
(4.40 - 20.36)
0.55
(0.36 - 0.82)
17.21
(5.98 - 49.57)
  1. For each fibrosis stage, we chose a low cut-off at 95% sensitivity (Se) used to predict the absence of the disease and a high cut-off at 95% specificity (Sp) used to predict the presence of the disease.
  2. Abbreviations: TP, true positive cases (correct diagnosis); FP, false positive cases (over-diagnosis); TN, true negative cases (correct diagnosis); FN, false negative cases (missed cases); Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; LR, likelihood ratio; DOR, diagnostic odds ratio; (*): values as percentage (%).