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Figure 1 | BMC Infectious Diseases

Figure 1

From: Endotoxin tolerance and cross-tolerance in mast cells involves TLR4, TLR2 and FcεR1 interactions and SOCS expression: perspectives on immunomodulation in infectious and allergic diseases

Figure 1

Effect of LPS prestimulation on expression of TLR4 and on TNFα production. The MC/9 mast cell line was prestimulated with LPS (10 and 100 ng/ml) and the expression of TLR4 (A) and the production of TNFα after a second challenge with LPS (1 μg/ml) (B) were determined by immunoblotting and ELISA, respectively. The production of TNFα was significantly reduced in a dose-dependent manner after prestimulation with LPS 100 ng/ml (* p < 0.01). However, this reduction was not mediated by a reduction in TLR4 expression, as shown. Values are mean and SEM from 3 independent experiments.

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