Determinants of seropositivity among HPV-16/18 DNA positive young women

BMC Infectious Diseases

Table 4 Determinants of seropositivity among HPV-18 DNA positive women at enrollment; Demographic and sexual factors.

Women characteristics	Anti-HPV18			Unadjusted		Final model¹
	Negative	Positive	%	OR	(95% CI)	OR	(95% CI)
All women	76	103	57.5
Age
18-19	17	27	61.4	1.00		1.00
20-21	25	31	55.4	0.78	(0.35-1.74)	0.83	(0.36-1.91)
22-23	21	24	53.3	0.72	(0.31-1.67)	0.85	(0.30-2.40)
24-25	13	21	61.8	1.02	(0.41-2.55)	1.23	(0.39-3.85)
p trend					0.92		0.73
Age at sexual debut
≥ 18	24	21	46.7	1.00		1.00
17	13	26	66.7	2.29	(0.94-5.55)	2.29	(0.94-5.55)
16	12	21	63.6	2.00	(0.80-5.02)	2.00	(0.80-5.02)
15	17	14	45.2	0.94	(0.38-2.36)	0.94	(0.38-2.36)
< 15	10	21	67.7	2.40	(0.92-6.23)	2.40	(0.92-6.23)
p trend					0.36		0.36
Years since first sexual intercourse
≤ 1	9	11	55.0	1.00		1.00
2-3	18	30	62.5	1.36	(0.47-3.92)	1.25	(0.40-3.93)
4-5	18	23	56.1	1.05	(0.36-3.06)	0.87	(0.28-2.75)
≥ 6	31	39	55.7	1.03	(0.38-2.80)	0.77	(0.25-2.41)
p trend					0.70		0.32
Frequency sexual intercourse, month
≤ 1	17	21	55.3	1.00		1.00
2-3	18	7	28.0	0.31	(0.11-0.93)	0.25	(0.08-0.78)
4-9	24	35	59.3	1.18	(0.52-2.69)	0.97	(0.39-2.39)
≥ 10	16	39	70.9	1.97	(0.83-4.68)	1.47	(0.57-3.81)
p trend					0.03		0.13
Lifetime number of sexual partners
1	20	28	58.3	1.00		1.00
2	18	22	55.0	0.87	(0.37-2.04)	0.89	(0.37-2.15)
≥ 3	38	53	58.2	1.00	(0.49-2.02)	1.02	(0.48-2.17)
p trend					0.96		0.91
Time with most recent partner, months
< 4	18	24	57.1	1.00		1.00
4-13	26	34	56.7	0.98	(0.44-2.17)	0.81	(0.35-1.91)
> 13	32	45	58.4	1.05	(0.49-2.26)	0.84	(0.35-2.04)
p trend					0.87		0.74

NOTE. HPV, human papillomavirus; OR, odds ratio; CI, confidence interval.
¹ For each variable considered the final model adjusts for all variables that changed the crude estimate of risk by 15% or more.
Age: was adjusted for years since first sexual intercourse.
Age at sexual debut: was not adjusted for any co-factors since none of the potential confounders evaluated changed the OR estimates by 15% or more.
Years since first sexual intercourse: was adjusted for use of hormonal contraceptives.
Frequency sexual intercourse, month: was adjusted for use of hormonal contraceptives.
Lifetime number of sexual partners: was adjusted for time with most recent partner.
Time with most recent partner: was adjusted for lifetime number of sexual partners and use of hormonal contraceptives.

ISSN: 1471-2334