Determinants of seropositivity among HPV-16/18 DNA positive young women

BMC Infectious Diseases

Table 1 Determinants of seropositivity among HPV-16 DNA positive women at enrollment; Demographic and sexual factors.

Women characteristics	Anti-HPV16			Unadjusted		Final model¹
	Negative	Positive	%	OR	(95% CI)	OR	(95% CI)
All women	179	305	63.0
Age
18-19	50	84	62.7	1.00		1.00
20-21	58	79	57.7	0.81	(0.50-1.32)	0.74	(0.44-1.25)
22-23	37	71	65.7	1.14	(0.67-1.94)	0.98	(0.51-1.86)
24-25	34	71	67.6	1.24	(0.73-2.13)	1.04	(0.53-2.06)
p trend					0.27		0.73
Age at sexual debut
≥ 18	53	83	61.0	1.00		1.00
17	33	63	65.6	1.22	(0.71-2.10)	1.22	(0.71-2.10)
16	37	60	61.9	1.04	(0.61-1.77)	1.04	(0.61-1.77)
15	34	57	62.6	1.07	(0.62-1.85)	1.07	(0.62-1.85)
< 15	22	42	65.6	1.22	(0.66-2.27)	1.22	(0.66-2.27)
p trend					0.69		0.69
Years since first sexual intercourse
≤ 1	23	27	54.0	1.00		1.00
2-3	45	75	62.5	1.42	(0.73-2.77)	1.28	(0.65-2.55)
4-5	45	74	62.2	1.40	(0.72-2.73)	1.23	(0.62-2.46)
≥ 6	66	129	66.2	1.66	(0.89-3.13)	1.40	(0.72-2.73)
p trend					0.15		0.39
Frequency sexual intercourse, month
≤ 1	46	48	51.1	1.00		1.00
2-3	26	52	66.7	1.92	(1.03-3.57)	1.85	(0.98-3.46)
4-9	59	110	65.1	1.79	(1.07-2.99)	1.55	(0.91-2.65)
≥ 10	45	92	67.1	1.96	(1.14-3.36)	1.57	(0.89-2.77)
p trend					0.03		0.20
Lifetime number of sexual partners
1	49	63	56.3	1.00		1.00
2	58	92	61.3	1.23	(0.75-2.03)	1.48	(0.87-2.50)
≥ 3	72	150	67.6	1.62	(1.02-2.59)	1.96	(1.19-3.25)
p trend					0.04		0.01
Time with most recent partner, months
< 4	52	69	57.0	1.00		1.00
4-13	56	98	63.6	1.32	(0.81-2.15)	1.24	(0.75-2.05)
> 13	71	138	66.0	1.46	(0.92-2.32)	1.54	(0.92-2.58)
p trend					0.11		0.10

NOTE. HPV, human papillomavirus; OR, odds ratio; CI, confidence interval.
¹ For each variable considered the final model adjusts for all variables that changed the crude estimate of risk by 15% or more.
Age: was adjusted for years since first sexual intercourse.
Age at sexual debut: was not adjusted for any co-factors since none of the potential confounders evaluated changed the OR estimates by 15% or more.
Years since first sexual intercourse: was adjusted for use of hormonal contraceptives.
Frequency sexual intercourse, month: was adjusted for use of hormonal contraceptives.
Lifetime number of sexual partners: was adjusted for time with most recent partner.
Time with most recent partner: was adjusted for lifetime number of sexual partners and use of hormonal contraceptives.

ISSN: 1471-2334