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Table 4 Streptococcus pneumoniae (Sp) meningitis case fatality ratios by age group and country [4, 5, 79]; Neisseria meningitidis meningitis case fatality ratios were available from Burkina Faso, Senegal, and Niger and summary means are presented for comparison.

From: African meningitis belt pneumococcal disease epidemiology indicates a need for an effective serotype 1 containing vaccine, including for older children and adults

Age (yrs) Burkina Faso* Senegal Niger* Ghana* Mean Sp CFR
(mortality)
Mean Nm
CFR (mortality§)
<1 52% 55% 58% 44% 53% (53) 12% (2.9)
1 to 4 50% 50% 57%   52% (7.4) 17% (3.3)
5 to 9 45% 48% 16%   36% (3.6) 10% (1.8)
10 to 14   50% 35%   43% (3.5) 10% (1.7)
15 to 19 44% 35% 62%   47% (3.5) 9% (1.0)
20 to 29   60% 58%   54% (3.1) 16% (0.8)
30 to 39   70% 20%   45% (4.2) 24% (0.8)
40 to 49   85% 60%   63% (7.9) 21% (0.6)
50 to 59   78%    61% (5.9) 43% (1.4)
60+   93%    66% (6.7) 43% (1.2)
  1. *Not all studies reported age groups at the detail shown in column 1. The CFRs in Burkina Faso for persons age 5 to 14 and 15+ years, in Niger for persons 40+ years, and in Ghana for all ages combined were 45%, 44%, 60%, and 44%, respectively.
  2. Weighted mean based on population under surveillance; Ghana was not included in the weighted means. Where data were not available from a study site for a specific age group, the next oldest age group was used in the calculation of the weighted mean.
  3. Nm = Neisseria meningitidis. For comparison, data on Nm are presented for the same surveillance periods and sites except for Ghana, which did not report these data.
  4. §Mortality rate per 100,000 per year, based on the product of the meningitis incidence rate and the case fatality ratio.