Table 2 Demographic and baseline characteristics (mITT population)
Tigecycline N = 97 | Imipenem/cilastatin N = 102 | Pvalue* | |
|---|---|---|---|
Mean ± SD age, years | 46.8 ± 18.2 | 41.0 ± 16.7 | 0.021 |
Sex, n (%) male | 65 (67.0) | 71 (69.6) | 0.694 |
Mean ± SD weight, kg | 63.2 ± 10.9 | 64.7 ± 11.1 | 0.335 |
Mean ± SD creatinine clearance, mL/min | 100.9 ± 37.5 | 108.8 ± 37.1 | 0.138 |
APACHE II score | 0.038 | ||
Mean ± SD | 5.1 ± 3.9 | 4.1 ± 2.7 | |
Median (range) | 4.0 (0.0 - 21.0) | 4.0 (0.0 - 12.0) | |
Primary intra-abdominal diagnosis, n (%) | 0.509 | ||
Complicated appendicitis | 74 (76.3) | 78 (76.5) | |
Complicated cholecystitis | 5 (5.2) | 7 (6.9) | |
Perforated duodenal ulcer | 3 (3.1) | 7 (6.9) | |
Peritonitis due to perforation of small intestine | 6 (6.2) | 2 (2.0) | |
Peritonitis due to perforation of large intestine | 4 (4.1) | 2 (2.0) | |
Perforated gastric ulcer | 1 (1.0) | 2 (2.0) | |
Complicated cholangitis | 2 (2.1) | 0 (0) | |
Post-traumatic peritonitis | 1 (1.0) | 1 (1.0) | |
Liver abscess | 1 (1.0) | 2 (2.0) | |
Perforated stomach | 0 (0) | 1 (1.0) |