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Table 2 Demographic and baseline characteristics (mITT population)

From: Efficacy and safety of tigecycline monotherapy vs. imipenem/cilastatin in Chinese patients with complicated intra-abdominal infections: a randomized controlled trial

  Tigecycline N = 97 Imipenem/cilastatin N = 102 Pvalue*
Mean ± SD age, years 46.8 ± 18.2 41.0 ± 16.7 0.021
Sex, n (%) male 65 (67.0) 71 (69.6) 0.694
Mean ± SD weight, kg 63.2 ± 10.9 64.7 ± 11.1 0.335
Mean ± SD creatinine clearance, mL/min 100.9 ± 37.5 108.8 ± 37.1 0.138
APACHE II score    0.038
   Mean ± SD 5.1 ± 3.9 4.1 ± 2.7  
   Median (range) 4.0 (0.0 - 21.0) 4.0 (0.0 - 12.0)  
Primary intra-abdominal diagnosis, n (%)    0.509
   Complicated appendicitis 74 (76.3) 78 (76.5)  
   Complicated cholecystitis 5 (5.2) 7 (6.9)  
   Perforated duodenal ulcer 3 (3.1) 7 (6.9)  
   Peritonitis due to perforation of small intestine 6 (6.2) 2 (2.0)  
   Peritonitis due to perforation of large intestine 4 (4.1) 2 (2.0)  
   Perforated gastric ulcer 1 (1.0) 2 (2.0)  
   Complicated cholangitis 2 (2.1) 0 (0)  
   Post-traumatic peritonitis 1 (1.0) 1 (1.0)  
   Liver abscess 1 (1.0) 2 (2.0)  
   Perforated stomach 0 (0) 1 (1.0)  
  1. NA = not available
  2. *Categorical baseline demographic and medical variables were analyzed using the Fisher exact test. Continuous variables were compared using a one-way analysis of variance (ANOVA) model with treatment as a factor.