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Table 5 Systematic review of the published studies on prevalence of HPV types in the general population in Italy

From: Prevalence of HPV high and low risk types in cervical samples from the Italian general population: a population based study

        percentage of positive in the population   
Author pub year Area N Age Population type of test HR+LR HR HPV16 HPV18 HPV16+18 Notes on molecular methods Notes on possible selection biases
Astori [24] 1997 Udine 197 mean 37.7 women referred to gynaecological clinic for genital complaints, Pap negative PCR My09/11 and RFLP analysis 20.3   5.1     
Ronco [8] 2005 Turin 1000 25-70 Invited in Organized Screening program PCR-EIA Gp5+/Gp6+ home made 8.8 7.1 2.8 0.1 2.9   
Centurioni [6] 2005 Genoa 503 mean 51 Opportunistic screening PCR Dot blot 15.9   9.1 5.8 14.9 the method is not actual any more The recruitment started in 1992
Tornesello [25] 2006 Milan and Neaples 207 median 40 asymptomatic attending clinic PCR home made and direct sequence 19.7 16.9 8.7 0 8.7   
Tornesello [26] 2007 Neaples 31 mean 28.9 migrant PCR nested (MY09-11 follwed by the inner GP5+/6+)followed by sequencing 35.5 25.8 6.4 0 6.4   
Ammatuna [9] 2008 Sicily 1006 18-24 random population sample Linear array HPV genotyping test (Roche) 24.1 17.4 4.5 1.3 5.8   
Tornesello [7] 2008 Neaples 115 mean 32.5 Opportunistic screening Home made Nested PCR followe by direct sequencing 13.9 13.9 6.9 0.9 7.8   
Del Prete [27] 2008 Apulia 871 >20; 85% = <50 women referred to hospital gynecologic visit PCR E1-E2 followed by gel 23.1 19.4 9.6 1.6 10.1   Not clear reason for referral, includes women referred for colposcopy
Agarossi [28] 2009 Italy 9947 15->65; 85% <50 asymptomatic attending clinic HCII followed by typing with Gp5+/Gp6+ PCR EIA Home made   14.8 4.3 1.5 5.6 no mention of negative control for PCR the sample includes women with previous positive Pap test
Giovannelli [29] 2009 Sicily 120 88% <40 Migrant attending Clinical visit PCR-Inno-LiPA 47.8 34.8 7.8 6 13.8   
Masia [30] 2009 Sardinia 815 >18; 83% = <45 Counselling for sexual activity or screening program PCR-EIA Gp5+/Gp6+ home made 31 20.3 8.2   13.5   
Verteramo [31] 2009 Rome 857 17-57 asymptomatic attending clinic PCR MY09/11 (and PCR with 4 pairs of primers to amplifiy E6 and E7 gene) followed by sequencing 31 13.3 4.4 0.8 5.3