Skip to main content

Advertisement

Table 1 Patients characteristics, timing and type of CMV infection/disease and of recurrence

From: Variable viral clearance despite adequate ganciclovir plasma levels during valganciclovir treatment for cytomegalovirus disease in D+/R- transplant recipients

# Age Sex Graft type date Diagnostic CMV Prophylaxis Intervala months CMV disease Log CMV DNA change/1st week Clearance of CMV viremia (Time to clearance) Recurrence of CMV disease (time from end of therapy) Immunosuppressive maintenance regimenb
1 64 M Liver Cirrhosis Child C VGCc 8.9 Colitis -1.2 Yes (34 days) No tacrolimus (10 μg/l)d
    19.02.2005 Alpha-antitrypsin deficiency 450 mg bid   (definite)     prednisone (7.5 qd)
      6 months       MMFe (stop for 1.5 months)
2 53 F Cardiac Idiopathic dilated VGC 6.2 Colitis -1.3 No No cyclosporine (200 μg/l)d
    26.05.2005 cardiomyopathy 450 mg bid   (definite)     prednisone (10 mg qd)
      3 months       MMFe (1000 mg bid)
3 46 M Kidney Drug toxicity: VGC 24.5 Syndrome -1.8 Yes (29 days) No tacrolimus (7 μg/l)d
    11.10.2004 cisplatin, ifosfamide, contrast 450 mg qd   (probable)     prednisone (5 mg qd)
     products, non steroidal analgesics 3 months       MPSf (180 mg bid)
4 62 M Kidney Hepatorenal polykystosis VGC 9.4 Syndrome -1.2 No Syndrome (probable) tacrolimus (8 μg/l)d
    24.03.2006   450 mg qd   (probable)    (21 days) prednisone (5 mg qd)
      3 months      Colitis (definite) (45 days) MMFe (500 mg bid)
5 49 M Liver Cirrhosis Child A None 1.4 Asymptomatic -0.8 Yes (28 days) No cyclosporine (240 μg/l)d
    03.07.2007 Hepatocellular carcinoma (HCV)    infection     prednisone (15 mg qd)
            AZAg (150 mg qd)
6 64 M Kidney Hepatorenal polykystosis VGC 9.7 Syndrome h -0.8 Yes (82 days) No tacrolimus (8 μg/l)d
    13.12.2006   450 mg qd   (probable)     prednisone (10 mg qd)
      3 months       MMFe (750 mg bid)
7 68 M Kidney Hypertension VGC 4.4 Syndrome 0 Yes (42 days) Gastritis (definite) tacrolimus (7 μg/l)d
    01.12.2006   450 mg qd   (probable)    (62 days) prednisone (5 mg qd)
      3 months       MMFe (250 mg bid)
  1. aInterval of time between transplantation and start of valganciclovir treatment
  2. bImmunosuppressive maintenance regimen when valganciclovir treatment was introduced
  3. cVGC = valganciclovir
  4. dtrough concentration
  5. eMMF = mycophenolate mofetil
  6. fMPS = mycophenolic sodium
  7. gAZA = azathioprine
  8. hThis patient received a shorter treatment because of serum creatinine increase (dehydration, diuretic and nephrotoxic drugs). The treatment was reintroduced 10 days after interruption.