Skip to main content

Table 1 Patients characteristics, timing and type of CMV infection/disease and of recurrence

From: Variable viral clearance despite adequate ganciclovir plasma levels during valganciclovir treatment for cytomegalovirus disease in D+/R- transplant recipients

#

Age

Sex

Graft type date

Diagnostic

CMV Prophylaxis

Intervala months

CMV disease

Log CMV DNA change/1st week

Clearance of CMV viremia

(Time to clearance)

Recurrence of CMV disease (time from end of therapy)

Immunosuppressive maintenance regimenb

1

64

M

Liver

Cirrhosis Child C

VGCc

8.9

Colitis

-1.2

Yes (34 days)

No

tacrolimus (10 μg/l)d

   

19.02.2005

Alpha-antitrypsin deficiency

450 mg bid

 

(definite)

   

prednisone (7.5 qd)

     

6 months

     

MMFe (stop for 1.5 months)

2

53

F

Cardiac

Idiopathic dilated

VGC

6.2

Colitis

-1.3

No

No

cyclosporine (200 μg/l)d

   

26.05.2005

cardiomyopathy

450 mg bid

 

(definite)

   

prednisone (10 mg qd)

     

3 months

     

MMFe (1000 mg bid)

3

46

M

Kidney

Drug toxicity:

VGC

24.5

Syndrome

-1.8

Yes (29 days)

No

tacrolimus (7 μg/l)d

   

11.10.2004

cisplatin, ifosfamide, contrast

450 mg qd

 

(probable)

   

prednisone (5 mg qd)

    

products, non steroidal analgesics

3 months

     

MPSf (180 mg bid)

4

62

M

Kidney

Hepatorenal polykystosis

VGC

9.4

Syndrome

-1.2

No

Syndrome (probable)

tacrolimus (8 μg/l)d

   

24.03.2006

 

450 mg qd

 

(probable)

  

(21 days)

prednisone (5 mg qd)

     

3 months

    

Colitis (definite)

(45 days)

MMFe (500 mg bid)

5

49

M

Liver

Cirrhosis Child A

None

1.4

Asymptomatic

-0.8

Yes (28 days)

No

cyclosporine (240 μg/l)d

   

03.07.2007

Hepatocellular carcinoma (HCV)

  

infection

   

prednisone (15 mg qd)

           

AZAg (150 mg qd)

6

64

M

Kidney

Hepatorenal polykystosis

VGC

9.7

Syndrome h

-0.8

Yes (82 days)

No

tacrolimus (8 μg/l)d

   

13.12.2006

 

450 mg qd

 

(probable)

   

prednisone (10 mg qd)

     

3 months

     

MMFe (750 mg bid)

7

68

M

Kidney

Hypertension

VGC

4.4

Syndrome

0

Yes (42 days)

Gastritis (definite)

tacrolimus (7 μg/l)d

   

01.12.2006

 

450 mg qd

 

(probable)

  

(62 days)

prednisone (5 mg qd)

     

3 months

     

MMFe (250 mg bid)

  1. aInterval of time between transplantation and start of valganciclovir treatment
  2. bImmunosuppressive maintenance regimen when valganciclovir treatment was introduced
  3. cVGC = valganciclovir
  4. dtrough concentration
  5. eMMF = mycophenolate mofetil
  6. fMPS = mycophenolic sodium
  7. gAZA = azathioprine
  8. hThis patient received a shorter treatment because of serum creatinine increase (dehydration, diuretic and nephrotoxic drugs). The treatment was reintroduced 10 days after interruption.