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Table 1 Features of 35 cryptococcal meningitis cases according to infecting species.

From: A prospective descriptive study of cryptococcal meningitis in HIV uninfected patients in Vietnam - high prevalence of Cryptococcus neoformans var grubii in the absence of underlying disease

   C. neoformansvar grubii C. neoformansvar gattii   
   (n = 25) (n = 10)   
Variable Value Value Odds ratio P Value
   (Range or %) (range or %) (95% CI)  
Median Age (range) 31 (15 - 74) 41 (18 - 53)   0.47
Male Sex 10 (40) 5 (50) 1.48 (0.26 - 8.4) 0.71
Underlying Disease 7 (28) 1 (10) 0.29 (0.01 - 2.9) 0.39
Symptoms
Fever 20 (80) 9 (90) 2.2 (0.2 - 117) 0.64
Headache 19 (90) 8 (89) 0.85 (0.04 - 55.8) 1.0
Vomiting 9 (36) 5 (50) 1.75 (0.31 - 10.1) 0.47
Blurred vision 12 (52) 4 (40) 0.62 (0.10 - 3.47) 0.71
Diplopia 4 (20) 2 (20) 1.0 (0.95 - 10.9) 1.0
Convulsions 4 (16) 1 (10) 0.59 (0.01 - 7.2) 0.59
Signs
GCS < 11/15 7 (28) 1 (10) 0.29 (0.01 - 2.9) 0.39
Neck Stiffness 22 (88) 8 (80) 0.56 (0.05 - 7.8) 0.61
Focal Neurological Signs 7 (28) 5 (50) 2.5 (0.4 - 15.0) 0.26
Papilloedema 5 (21) 5 (50) 3.63 (0.6 - 24.3) 0.11
Investigations     
Abnormal Chest X-ray 8 (32) 2 (20) 0.54 (0.05 - 3.7) 0.69
Abnormal Brain Imaginga 7 (58) 7(100) - 0.13
Haematocrit 37.8 (25.3 - 51.4) 38.8 (31.1 - 46)   0.65
Blood White Cell Count (×10^9/ml) 11.5(3.3 - 26.6) 13.6 (7.1 - 26.1)   0.37
Platelet count (×10^9/L) 256 (56.9 - 356) 305 (140 - 487)   
CSF opening pressure (cmCSF)b 34.2 (2 - > 40) 30.5 (15 - > 40)   0.44
CSF White Cell Count/ml 287 (2 - 1080) 279 (12 - 480)   0.18
CSF Lymphocyte %c 53 (12 - 97) 56 (19 - 93)   0.74
CSF Protein (g/L) 1.28 (0.35 - 2.63) 1.25 (0.4 - 1.94)   0.9
Log2 CSF Cryptococcal antigen titre5 7.4 (3 - 15) 8.6 (2 - 14)   0.5
Lactate (mmol/L) 6.2 (1.6 - 22.5) 4.2 (2 - 8.4)   0.052
Antifungal MICs (mg/L)    
Amphotericin GM(95%CI) 0.71 (0.62 - 0.83) 0.45 (0.34 - 0.60)   0.01
  MIC90 1.0 0.5   
Flucytosine GM(95%CI) 8.23 (7.22 - 9.37) 1.85 (1.18 - 2.90)   < 0.001
  MIC90 16/0 4.0   
Fluconazole GM(95%CI) 6.96 (5.11 - 9.49) 4.54 (2.44 - 8.42)   0.19
  MIC90 16.0 16.0   
Itraconazole GM(95%CI) 0.11 (0.08 - 0.14) 0.9 (0.05 - 0.14)   0.48
  MIC90 0.26 0.26   
Voriconazole GM(95%CI) 0.07 (0.05 - 0.09) 0.06 (0.04 - 0.51)   0.85
  MIC90 0.13 0.26   
Posaconazole GM(95%CI) 0.13 (0.10 - 0.17) 0.10 (0.06 - 0.17)   0.336
  MIC90 0.26 0.26   
  1. aN = 26, bN = 33, cN = 32, dN = 31
  2. GM = Geometric Mean
  3. MIC90 = minimum inhibitory concentration 90