| | |
C. neoformansvar grubii
|
C. neoformansvar gattii
| | |
|---|
| | |
(n = 25)
|
(n = 10)
| | |
|---|
|
Variable
|
Value
|
Value
|
Odds ratio
|
P Value
|
|---|
| | |
(Range or %)
|
(range or %)
|
(95% CI)
| |
|---|
|
Median Age (range)
|
31 (15 - 74)
|
41 (18 - 53)
| |
0.47
|
|
Male Sex
|
10 (40)
|
5 (50)
|
1.48 (0.26 - 8.4)
|
0.71
|
|
Underlying Disease
|
7 (28)
|
1 (10)
|
0.29 (0.01 - 2.9)
|
0.39
|
|
Symptoms
|
|
Fever
|
20 (80)
|
9 (90)
|
2.2 (0.2 - 117)
|
0.64
|
|
Headache
|
19 (90)
|
8 (89)
|
0.85 (0.04 - 55.8)
|
1.0
|
|
Vomiting
|
9 (36)
|
5 (50)
|
1.75 (0.31 - 10.1)
|
0.47
|
|
Blurred vision
|
12 (52)
|
4 (40)
|
0.62 (0.10 - 3.47)
|
0.71
|
|
Diplopia
|
4 (20)
|
2 (20)
|
1.0 (0.95 - 10.9)
|
1.0
|
|
Convulsions
|
4 (16)
|
1 (10)
|
0.59 (0.01 - 7.2)
|
0.59
|
|
Signs
|
|
GCS < 11/15
|
7 (28)
|
1 (10)
|
0.29 (0.01 - 2.9)
|
0.39
|
|
Neck Stiffness
|
22 (88)
|
8 (80)
|
0.56 (0.05 - 7.8)
|
0.61
|
|
Focal Neurological Signs
|
7 (28)
|
5 (50)
|
2.5 (0.4 - 15.0)
|
0.26
|
|
Papilloedema
|
5 (21)
|
5 (50)
|
3.63 (0.6 - 24.3)
|
0.11
|
|
Investigations
| | | | |
|
Abnormal Chest X-ray
|
8 (32)
|
2 (20)
|
0.54 (0.05 - 3.7)
|
0.69
|
|
Abnormal Brain Imaginga
|
7 (58)
|
7(100)
|
-
|
0.13
|
|
Haematocrit
|
37.8 (25.3 - 51.4)
|
38.8 (31.1 - 46)
| |
0.65
|
|
Blood White Cell Count (×10^9/ml)
|
11.5(3.3 - 26.6)
|
13.6 (7.1 - 26.1)
| |
0.37
|
|
Platelet count (×10^9/L)
|
256 (56.9 - 356)
|
305 (140 - 487)
| | |
|
CSF opening pressure (cmCSF)b
|
34.2 (2 - > 40)
|
30.5 (15 - > 40)
| |
0.44
|
|
CSF White Cell Count/ml
|
287 (2 - 1080)
|
279 (12 - 480)
| |
0.18
|
|
CSF Lymphocyte %c
|
53 (12 - 97)
|
56 (19 - 93)
| |
0.74
|
|
CSF Protein (g/L)
|
1.28 (0.35 - 2.63)
|
1.25 (0.4 - 1.94)
| |
0.9
|
|
Log2 CSF Cryptococcal antigen titre5
|
7.4 (3 - 15)
|
8.6 (2 - 14)
| |
0.5
|
|
Lactate (mmol/L)
|
6.2 (1.6 - 22.5)
|
4.2 (2 - 8.4)
| |
0.052
|
|
Antifungal MICs (mg/L)
| | | |
|
Amphotericin
|
GM(95%CI)
|
0.71 (0.62 - 0.83)
|
0.45 (0.34 - 0.60)
| |
0.01
|
| |
MIC90
|
1.0
|
0.5
| | |
|
Flucytosine
|
GM(95%CI)
|
8.23 (7.22 - 9.37)
|
1.85 (1.18 - 2.90)
| |
< 0.001
|
| |
MIC90
|
16/0
|
4.0
| | |
|
Fluconazole
|
GM(95%CI)
|
6.96 (5.11 - 9.49)
|
4.54 (2.44 - 8.42)
| |
0.19
|
| |
MIC90
|
16.0
|
16.0
| | |
|
Itraconazole
|
GM(95%CI)
|
0.11 (0.08 - 0.14)
|
0.9 (0.05 - 0.14)
| |
0.48
|
| |
MIC90
|
0.26
|
0.26
| | |
|
Voriconazole
|
GM(95%CI)
|
0.07 (0.05 - 0.09)
|
0.06 (0.04 - 0.51)
| |
0.85
|
| |
MIC90
|
0.13
|
0.26
| | |
|
Posaconazole
|
GM(95%CI)
|
0.13 (0.10 - 0.17)
|
0.10 (0.06 - 0.17)
| |
0.336
|
| |
MIC90
|
0.26
|
0.26
| | |
-
aN = 26, bN = 33, cN = 32, dN = 31
- GM = Geometric Mean
- MIC90 = minimum inhibitory concentration 90
