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Table 1 Patient demographics and baseline characteristics

From: Caspofungin Use in Daily Clinical Practice for Treatment of Invasive Aspergillosis: Results of a Prospective Observational Registry

Variable Monotherapy
(N = 85)
Combination therapy
(N = 18)
Overall
(N = 103)
Gender, n (%)    
   Male 55 (64.7%) 11 (61.1%) 66 (64.1%)
   Female 30 (35.3%) 7 (38.9%) 37 (35.9%)
Mean age (years) (mean ± SDa) 49.8 ± 15.94 53.4 ± 16.94 50.4 ± 16.09
Race, n (%)    
   White 49 (57.6%) 15 (83.3%) 64 (62.1%)
   Asian 36 (42.4%) 3 (16.7%) 39 (37.9%)
Country, n (%)    
   Germany 36 (42.4%) 6 (33.3%) 42 (40.8%)
   Korea 28 (32.9%) 3 (16.7%) 31 (30.1%)
   Russia 8 (9.4%) 0 8 (7.8%)
   Taiwan 6 (7.1%) 0 6 (5.8%)
   Greece 0 5 (27.8%) 5 (4.8%)
   Other 7 (8.2%) 4 (22.2%) 11 (10.7%)
Mean APACHE II score (mean ± SD) 18.3 ± 8.26 (n = 11) 18.3 ± 2.52 (n = 3) 18.3 ± 7.31 (n = 14)
SOFA score (mean ± SD) 8.8 ± 4.66 (n = 5) 0 8.8 ± 4.66 (n = 5)
Site of Infection, n (%)    
   Blood 8 (9.4%) 0 8 (7.8%)
   Lung 72 (84.7%) 15 (83.3%) 87 (84.5%)
   Bone/joint 1 (1.2%) 0 1 (1.0%)
   Sinus 0 1 (5.6%) 1 (1.0%)
   Liver/spleen 0 1 (5.6%) 1 (1.0%)
   Other 2 (2.4%) 0 2 (1.9%)
   Multiple 2 (2.4%) 1 (5.6%) 3 (2.9%)
Neutropenic at time of initiation of
caspofungin treatment, n (%)
   
   <500 cells/μL 53 (62.4%) 6 (33.3%) 59 (57.3%)
   >500 cells/μL 32 (37.6%) 12 (66.7%) 44 (42.7%)
Number of risk factors per patient
(mean ± SD)
5.4 ± 1.76 4.8 ± 1.86 5.3 ± 1.78
Risk factors and underlying medical conditionsb, n (%)    
   Active malignancy 70 (82.4%) 9 (50%) 79 (76.7%)
   Immunosuppressive medication 64 (75.3%) 12 (66.7%) 76 (73.8%)
   Neutropenia at time of hospitalization 59 (69.4%) 7 (38.9%) 66 (64.1%)
   Allogeneic HSCT 18 (21.2%) 5 (27.8%) 23 (22.3%)
   Prior fungal colonization 16 (18.8%) 2 (11.1%) 18 (17.5%)
   Diabetes mellitus 11 (12.9%) 4 (22.2%) 15 (14.6%)
   Organ transplantation 5 (5.9%) 4 (22.2%) 9 (8.7%)
   Autologous HSCT 5 (5.9%) 0 5 (4.9%)
   AIDS/HIV infection 3 (3.5%) 0 3 (2.9%)
  1. aSD = standard deviation
  2. bFrequencies of different risk factors and underlying medical conditions are not mutually exclusive.