Venn Diagrams. Schematic of the spatial and temporal gene expression in the experimental groups. The numbers in the circles represent the number of transcripts which are significantly up- or down-regulated in a given condition. A) Comparison of the extent of transcriptional regulation within the cortex and the hippocampus in relation to the time after infection. In contrast to the cortex which shows the highest number of regulated genes at 1 day after infection, the transcriptional regulation in the hippocampus peaks 3 days after infection. B) In the early acute phase of the disease at 1 day after infection, the hippocampus and the cortex share ~60% of the significantly regulated transcripts. At 3 days after infection, in the late acute phase, the number of co-regulated genes drops to 50% for the cortex and 18% for the hippocampus.