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Table 2 Assumptions for pharmacokinetic parameters used during simulations

From: Pharmacokinetic-pharmacodynamic profiling of four antimicrobials against Gram-negative bacteria collected from Shenyang, China

Antibiotic Pharmacokinetic (mean ± SD) Reference
  CLT (liters/h) Vd (liters) Fraction unbound (%) AUC0-24  
Meropenem 14.4 ± 1.8 18.6 ± 3.0 0.85-0.98 - 2
Imipenem 10.5 ± 1.4 15.3 ± 3.3 0.80-0.95 - 2
Cefepime 5.3 ± 0.6 13.6 ± 2.4 0.8-0.9 - 2
Piperacillin/tazobactam 10.9 ± 1.2 11.9 ± 1.7 0.65-0.75 - 2
Levofloxacin - - - 48 ± 8 3