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Table 2 Assumptions for pharmacokinetic parameters used during simulations

From: Pharmacokinetic-pharmacodynamic profiling of four antimicrobials against Gram-negative bacteria collected from Shenyang, China

Antibiotic

Pharmacokinetic (mean ± SD)

Reference

 

CLT (liters/h)

Vd (liters)

Fraction unbound (%)

AUC0-24

 

Meropenem

14.4 ± 1.8

18.6 ± 3.0

0.85-0.98

-

2

Imipenem

10.5 ± 1.4

15.3 ± 3.3

0.80-0.95

-

2

Cefepime

5.3 ± 0.6

13.6 ± 2.4

0.8-0.9

-

2

Piperacillin/tazobactam

10.9 ± 1.2

11.9 ± 1.7

0.65-0.75

-

2

Levofloxacin

-

-

-

48 ± 8

3