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Table 2 Seroconversion during and post-prophylaxis in the study population

From: Seroconversion and asymptomatic infections during oseltamivir prophylaxis against Influenza A H1N1 2009

 

Overall

(n = 237)

Outbreak A

(n = 149)

Outbreak B

(n = 42)

Outbreak C

(n = 46)

Date of 1st blood sample

23 Jun-16 Jul 10

23 Jun 10

9 Jul 10

16 Jul 10

Date of 2nd blood sample

13 Jul-6 Aug 10

13 Jul 10

30 Jul 10

6 Aug 10

Date of 3rd blood sample

21-25 Aug 10

21 Aug 10

25 Aug 10

25 Aug 10

Seroconversion during prophylaxis (second vs first samples)*

    

   Total

16/226 (7.1%)

10/141 (7.1%)

4/40 (10%)

2/45 (4.4%)

   Symptomatic

8/226 (3.5%)

3/141 (2.1%)

3/40 (7.5%)

2/45 (4.4%)

   Asymptomatic (and RT-PCR negative)

8/226 (3.5%)

7/141 (5.0%)

1/40 (2.5%)

0/45 (0.0%)

Overall infection rate during outbreak (serological and index cases)

27/237 (11.4%)

18/149 (12.1%)

6/42 (14.3%)

3/46 (6.5%)

Seroconversion post-prophylaxis (third vs second samples)

    

   Total

23/190 (12.1%)

16/115 (13.9%)

1/34 (2.9%)

6/41 (14.6%)

   Symptomatic

4/190 (2.1%)

2/115 (1.7%)

1/34 (2.9%)

1/41 (2.4%)

   Asymptomatic

19/190 (10.0%)

14/115 (12.2%)

0/34 (0.0%)

5/41 (12.2%)

  1. *Excluding index cases