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Table 5 Allele richness (R s ), expected heterozygosity (H e ) and F S T estimates at flanking and neutral microsatellites of P. falciparum dhps genotypes

From: Tracing the origins and signatures of selection of antifolate resistance in island populations of Plasmodium falciparum

  

dhpsgenotypes

Microsatellites

Wild type (N= 26)

Single mutant (N= 154)

Double mutant (N= 15)

all samples (N= 195)

  

R s

H e

R s

H e

R s

H e

R s

H e

F ST

P

Loci flanking dhps gene

Dhps 0.8

8

0.91

4

0.47

5

0.79

6

0.71

0.25

<0.0001

 

Dhps 4.3

6

0.85

4

0.53

3

0.26

4

0.55

0.30

<0.0001

 

Dhps 7.7

8

0.90

10

0.92

3

0.28

9

0.71

0.12

0.02

 

Over all loci

7

0.82

6

0.63

4

0.45

6

0.66

0.22

<0.0001

Loci flanking dhfr gene

Dhfr 0.3

5

0.68

6

0.72

5

0.76

6

0.72

0.02

NS

 

Dhfr 4.4

4

0.49

5

0.44

2

0.13

5

0.36

<-0.01

NS

 

Dhfr 5.3

5

0.66

5

0.63

3

0.53

5

0.61

-0.01

NS

 

Over all loci

5

0.61

5

0.60

3

0.47

5

0.56

0.01

NS

Neutral loci

TAA81

7

0.84

7

0.83

6

0.83

7

0.83

0.01

NS

 

TA109

6

0.74

8

0.77

4

0.50

8

0.67

0.01

NS

 

TA87

9

0.87

9

0.87

7

0.87

9

0.87

<0.01

NS

 

PfPK2

7

0.85

10

0.88

6

0.86

10

0.86

0.01

NS

 

Over all loci

7

0.83

9

0.84

6

0.77

9

0.81

0.01

NS

  1. N: Number of isolates genotyped. All loci: mean over loci Rs and He and global F ST over loci as calculated by FSTAT. P: P-values of permutation tests to assess significance of F ST values. NS: non-significant (P > 0.05). In bold: significant after Bonferroni corrections for multiple tests.
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BMC Infectious Diseases

ISSN: 1471-2334

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