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Table 2 In vitro activity of 9 generic products of oxacillin and the innovator against two strains of S. aureus.

From: In vitro and in vivo comparison of the anti-staphylococcal efficacy of generic products and the innovator of oxacillin

OXACILLIN (OXA) PRODUCTS

S. aureusATCC 29213

S. aureusGRP-0057

 

MIC (mg/L)

MBC (mg/L)

MBC/MIC Ratio

MIC (mg/L)

MBC (mg/L)

MBC/MIC Ratio

OXA-BMS (innovator)

0.22

0.40

1.78

0.16

0.25

1.59

OXA-BLA

0.50

0.50

1.00

0.18

0.50

2.83

OXA-CAR

0.50

1.00

2.00

0.50

0.50

1.00

OXA-COL

0.50

0.71

1.41

0.18

0.35

2.00

OXA-MEM

0.13

0.13

1.00

0.13

0.13

1.00

OXA-OPH

0.25

0.71

2.83

0.18

0.25

1.41

OXA-PEN

0.25

0.35

1.41

0.18

0.21

1.19

OXA-QIM

0.50

1.00

2.00

0.18

0.25

1.41

OXA-SER

0.25

0.50

2.00

0.25

0.50

2.00

OXA-VIT

0.13

0.13

1.00

0.13

0.13

1.00

Exact P (KW*)

0.2115

0.2110

0.2611

0.3650

0.1339

0.2751

  1. Values represent geometric means of each MIC, MBC and MBC/MIC ratio, obtained from 1 to 3 duplicate determinations (ranges not included for brevity and clarity). * Kruskal-Wallis test.