Figure 3

Dose-response relationship of the innovator and 9 generic products of oxacillin in the neutropenic mouse thigh infection model. OXA-BMS (innovator, black curve) and 8 generics fitted to Hill's sigmoid model, while generic product OXA-SER fitted to the Gaussian U-shaped model (red curve). Regardless of pharmaceutical equivalence and in vitro activity, all generics displayed significantly inferior bactericidal efficacy (P < 0.0001) or different pharmacodynamic behavior (Gaussian instead of sigmoid) compared with the innovator, thus lacking therapeutic equivalence.