Skip to main content

Table 2 Sensitivity and specificity, positive and negative predictive values of each assay against the gold standard algorithm

From: Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses

Assay parameter

Patients (n =)

Acute Dengue cases (n =)

Number positive in rapid test (n =)

Sensitivity %

(95% CI)

Specificity %

(95% CI)

PPV %

(95% CI)

NPV (%)

(95% CI)

BR NS1

292

245

151

61.6

(55.2 - 67.8)

100

(93.8 - 100)a

100

(98.0 - 100)a

33.3

(25.6 - 41.8)

SD NS1 alone

292

245

153

62.4

(56.1 - 68.5)

100

(93.8 - 100)a

100

(98.1 - 100)a

33.8

(26.0 - 42.3)

SD NS1 or IgMb

292

245

185

75.5

(69.6 - 80.8)

100

(93.8 - 100)a

100

(98.4 - 100)a

43.9

(34.3 - 53.9)

SD NS1 or IgM or IgGb

292

245

206

83.7

(78.4 - 88.1)

97.9

(88.7 - 99.9)

99.5

(97.3 - 100.0)

53.5

(42.4 - 64.3)

  1. aone-sided, 95% Confidence Interval
  2. bthe detection of IgM or IgG in the rapid test is not sufficient for a definitive diagnosis of dengue and results are reported here for comparative purposes only