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Table 4 Post-hoc analysis in which post-vaccination geometric mean titres (GMTs) were adjusted according to pre-vaccination titres and ratios of GMT (adjuvanted vaccine/intradermal vaccine) for the three virus strains on day 21 in the per protocol set assessed by haemagglutinin inhibition (HI) and single radial haemolysis (SRH) methods

From: Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study

 

HI method (1/dil)

SRH method (mm2)

 

Intradermal vaccine

(N = 390)

Adjuvanted vaccine

(N = 385)

 

Intradermal vaccine

(N = 389)

Adjuvanted vaccine

(N = 382)

 

Virus strain

Post-vaccination GMT

[95% CI]

Ratios of GMT

[95% CI]

Post-vaccination GMT

[95% CI]

Ratios of GMT

[95% CI]

A/H1N1

108.8

121.6

1.12

47.1

54.0

1.15

 

[97.4;121.5]

[108.8;135.9]

[0.95;1.31]*

[42.8;51.9]

[49.0;59.6]

[1.00;1.32]*

A/H3N2

266.5

332.8

1.25

40.3

45.3

1.12

 

[243.1;292.3]

[303.3;365.2]

[1.10;1.42]*

[37.0;44.0]

[41.5;49.4]

[0.99;1.27]*

B

37.9

38.9

1.03

65.8

69.8

1.06

 

[35.0;41.0]

[35.9;42.1]

[0.92;1.15]*

[61.0;71.1]

[64.6;75.4]

[0.95;1.18]*

  1. * Non-inferiority of the ID vaccine was demonstrated if the upper bound of the 95% CI for the ratios of GMT was < 1.5
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BMC Infectious Diseases

ISSN: 1471-2334

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