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Table 3 Post-vaccination geometric mean titres (GMT) and ratios of GMT (adjuvanted vaccine/intradermal vaccine) for the three virus strains on day 21 in the per protocol set assessed by the haemagglutinin inhibition (HI) and single radial haemolysis (SRH) methods

From: Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study

   HI method (1/dil) SRH method (mm2)
   Intradermal vaccine
(N = 390)
Adjuvanted vaccine
(N = 385)
  Intradermal vaccine
(N = 389)
Adjuvanted vaccine
(N = 382)
 
Virus strain Pre or Post vaccination GMT
[95% CI]
Ratios of GMT
[95% CI]
GMT [95% CI] Ratios of GMT
[95% CI]
A/H1N1 Pre- 13.3 [12.1;14.6] 13.5 [12.3;14.9] -- 7.7 [6.9;8.6] 8.0 [7.2;8.9] --
  Post- 108.3 [95.4;123.0] 122.1 [109.1;136.7] 1.13 [0.95;1.34]* 46.4 [41.6;51.8] 53.9 [49.0;59.3] 1.16 [1.00;1.34]*
A/H3N2 Pre- 60.3 [52.2;69.7] 69.4 [59.5;81.0] -- 11.0 [9.8;12.5] 12.7 [11.2;14.3] --
  Post- 259.9 [233.5;289.3] 341.4 [306.7;380.1] 1.31 [1.13;1.53] 39.3 [35.6;43.3] 46.2 [42.1;50.7] 1.18 [1.03;1.34]*
B Pre- 15.0 [13.7;16.4] 16.5 [15.1;18.1] -- 29.2 [25.6;33.2] 28.0 [24.5;32.1) --
  Post- 36.9 [33.6;40.5] 39.9 [36.4;43.8] 1.08 [0.95;1.23]* 66.5 [60.8;72.8] 68.9 [62.9;75.3] 1.03 [0.91;1.17]*
  1. *Non-inferiority of the intradermal vaccine was demonstrated if the upper bound of the 95% CI for the ratios of GMT was < 1.5.