Table 3 Post-vaccination geometric mean titres (GMT) and ratios of GMT (adjuvanted vaccine/intradermal vaccine) for the three virus strains on day 21 in the per protocol set assessed by the haemagglutinin inhibition (HI) and single radial haemolysis (SRH) methods
HI method (1/dil) | SRH method (mm2) | ||||||
|---|---|---|---|---|---|---|---|
Intradermal vaccine (N = 390) | Adjuvanted vaccine (N = 385) | Intradermal vaccine (N = 389) | Adjuvanted vaccine (N = 382) | ||||
Virus strain | Pre or Post vaccination | GMT [95% CI] | Ratios of GMT [95% CI] | GMT [95% CI] | Ratios of GMT [95% CI] | ||
A/H1N1 | Pre- | 13.3 [12.1;14.6] | 13.5 [12.3;14.9] | -- | 7.7 [6.9;8.6] | 8.0 [7.2;8.9] | -- |
Post- | 108.3 [95.4;123.0] | 122.1 [109.1;136.7] | 1.13 [0.95;1.34]* | 46.4 [41.6;51.8] | 53.9 [49.0;59.3] | 1.16 [1.00;1.34]* | |
A/H3N2 | Pre- | 60.3 [52.2;69.7] | 69.4 [59.5;81.0] | -- | 11.0 [9.8;12.5] | 12.7 [11.2;14.3] | -- |
Post- | 259.9 [233.5;289.3] | 341.4 [306.7;380.1] | 1.31 [1.13;1.53] | 39.3 [35.6;43.3] | 46.2 [42.1;50.7] | 1.18 [1.03;1.34]* | |
B | Pre- | 15.0 [13.7;16.4] | 16.5 [15.1;18.1] | -- | 29.2 [25.6;33.2] | 28.0 [24.5;32.1) | -- |
Post- | 36.9 [33.6;40.5] | 39.9 [36.4;43.8] | 1.08 [0.95;1.23]* | 66.5 [60.8;72.8] | 68.9 [62.9;75.3] | 1.03 [0.91;1.17]* | |