Human immunodeficiency virus type I-specific CD8+T cell subset abnormalities in chronic infection persist through effective antiretroviral therapy

Table 1 General characteristics and changes for subjects with undetectable HIV replication

ID	Duration of infection	^aVL zenith	^bCD4 nadir	^cDuration of suppression	^dCD4_i	CD4_f	^eMonths study course	^fCD8⁺ IFNγ⁺ CD45RA⁺ _i	CD8⁺ IFNγ⁺ CD45RA⁺ _f
27	>15 yrs	5.13	308	21 months	702	1364	90	13%	26%
30	>15 yrs	4.53	314	84 months	630	1089	28	ND	ND
50	>15 yrs	5.45	18	7 months	220	627	108	52%	50%
62	>15 yrs	4.61	154	32 months	738	756	28	10%	15%
90	>15 yrs	6.22	73	24 months	280	352	96	79%	84%
109	>15 yrs	3.66	145	72 months	740	665	24	22%	16%
128	>12 yrs	4.53	364	3 months	570	912	66	44%	52%
134	>12 yrs	5.01	96	72 months	850	1020	24	ND	ND
143	>10 yrs	4.77	400	24 months	400	682	60	ND	22%
149	>9 yrs	5.67	9	36 months	338	264	24	ND	ND
155	>9 yrs	5.10	210	3 months	368	408	54	10%	10%
174	>7 yrs	5.53	380	12 months	494	768	30	ND	ND
176	>7 yrs	<2.6	245	12 months	361	750	36	ND	ND
193	>6 yrs	<2.6	40	12 months	405	324	24	23%	13%
200	>5 yrs	>5.88	192	3 months	567	957	24	ND	ND

^aThe highest recorded virus load (VL) for each subject in log₁₀ copies HIV RNA/mL plasma.
^bThe lowest recorded peripheral blood CD4⁺ T lymphocyte count for each subject.
^cThe length of time before analysis of HIV-specific CD8⁺ T cell responses for which each subject experienced suppression of viremia below detectable levels.
^dThe number of CD4⁺ T lymphocytes/μL peripheral blood for each subject at beginning (CD4_i) and end (CD4_f) of period over which HIV-specific CD8⁺ T cell responses were assessed.
^eTotal time period over which four assessments of HIV-specific CD8⁺ T cell responses occurred.
^fPercentage of HIV-specific CD8⁺ T cells producing INF-γ that expressed CD45RA at beginning (_i) and end (_f) of period over which HIV-specific CD8⁺ T cell responses were assessed.

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