Advertisement
Table 1 Characteristics of 495 patients who received prophylaxis and 165 patients who did not receive prophylaxis
| Characteristics | Primary prophylaxis | Secondary prophylaxis | No prophylaxis | ||||
|---|---|---|---|---|---|---|---|
| CD4 <200/μL | CD4 ≧200/μL | P value | CD4 <200/μL | CD4 ≧200/μL | P value | ||
| Patient number, n | 211 | 68 | 145 | 71 | 165 | ||
| Age at enrollment, mean (SD), y | 39.0 (12.0) | 35.0 (10.7) | 0.03 | 38.6 (10.2) | 35.0 (8.4) | 0.006 | 37.0 (10.9) |
| Male sex, n (%) | 195 (92.4) | 66 (97.1) | 0.26 | 134 (92.4) | 68 (95.8) | 0.56 | 152 (92.1) |
| Risk behaviors, no (%) | |||||||
| MSM | 138 (65.4) | 48 (70.6) | 0.74 | 89 (61.4) | 58 (81.7) | 0.22 | 110 (66.7) |
| Heterosexual | 68 (32.2) | 17 (25.0) | 0.47 | 50 (34.5) | 10 (14.1) | 0.02 | 41 (24.8) |
| Others | 5 (2.4) | 3 (4.4) | 0.41 | 6 (4.1) | 3 (4.2) | 0.99 | 14 (8.5) |
| Nadir CD4 count, median (range), cells/μL | 27 (1-182) | 93 (67-194) | <0.001 | 17 (0-165) | 40 (1-174) | <0.001 | 134 (4-199) |
| Baseline PVL, median (range), log10 copies/ml | 5.46 (2.60-6.12) | 5.60 (2.60-6.19) | 0.13 | 5.56 (2.60-5.99) | 5.72 (3.09-5.98) | 0.04 | 5.14 (2.60-5.88) |
| Chemoprophylaxis, n (%) | |||||||
| Trimethoprim-sulfamethoxazole | 207 (98.1) | 67 (98.5) | 1 | 142 (97.9) | 71 (100) | 1 | NA |
| Clindamycin/primaquine | 2 (0.9) | 2 (2.9) | 0.26 | 29 (20.0) | 15 (21.1) | 0.86 | NA |
| Macrolides | 16 (9.0) | 5 (7.4) | 1 | 6 (4.1) | 7 (9.9) | 0.14 | NA |
| Duration of prophylaxis, median (range), m | 2.0 (0.2-66.2) | 5.3 (0.25-47.8) | 0.036 | 2.7 (0.1-62) | 4.0 (0.34-57) | 0.04 | |
| CD4 at discontinuation of prophylaxis | |||||||
| median (range), cells/ul | 101 (2-199) | 234 (207-642) | <0.001 | 111 (5-197) | 279 (201-880) | <0.001 | |
| <100 cells/ul, n (%) | 101 (47.9) | 0 (0) | 53 (36.6) | 0 (0) | |||
| PVL at discontinuation of prophylaxis, median (range), log10 copies/ml | 2.60 (2.60-5.88) | 2.60 (2.60-5.15) | 0.027 | 2.60 (2.60-5.88) | 2.60 (2.60-5.51) | 0.022 | NA |
| PVL < 400 copies/ml, no (%) | 130 (61.6) | 55 (80.9) | 0.24 | 85 (58.6) | 53 (74.6) | 0.31 | NA |
| Latest CD4, median (range), cells/ul | 200 (2-214) | 376 (0-952) | 0.019 | 200 (2-215) | 426 (2-1124) | 0.005 | 200 (4-209) |
| <200 cells/ul, n (%) | 78 (37.0) | 15 (22) | 0.11 | 41 (28.3) | 10 (14.1) | 0.09 | 49 (29.7) |
