CAL | HALa | ||
---|---|---|---|
Variables | No. (%) of episodes | No. (%) of episodes | p-valueb |
Initial antibiotic therapy | |||
Use of an anti-legionella antibioticc | 34 (12.5) | 5 (8.3) | 0.38 |
Use of >1 antibiotic (± anti-legionella antibiotics) | 54 (19.9) | 20 (33.3) | 0.14 |
Penicillin monotherapy | 144 (52.9) | 16 (26.7) | <0.001* |
Anti-legionella antibiotic treatment | |||
Anti-legionella antibiotic ≤ 24 hoursd | 48 (17.6) | 6 (10.0) | x |
Anti-legionella antibiotic > 24 hoursd | 201 (73.9) | 42 (70.0) | x |
No anti-legionella antibiotic during admission | 18 (6.6) | 7 (11.7) | 0.24 |
Delay of anti-legionella therapy (median and IQR) | |||
Days from admission | 2 (1-4) | X | x |
Days from symptom onset | 7 (5-11) | 7 (3-12) | 0.29 |
Duration of anti-legionella therapy (median and IQR) | |||
Died in hospital | 7 (2-13) | 6 (2-13) | 0.79 |
Discharged alive | 21 (14-23) | 20 (13-27) | 0.65 |
Antibiotics used during admission | |||
Macrolide monotherapye | 87 (32.0) | 18 (30.0) | 0.97 |
Fluoroquinolone monotherapyf | 4 (1.5) | 3 (5.0) | 0.07 |
Macrolide + Rifampicin | 39 (14.3) | 5 (8.3) | 0.26 |
Fluoroquinolone + Rifampicin | 11 (4.0) | 3 (5.0) | 0.67 |
Macrolide + Fluoroquinolone | 44 (16.2) | 9 (15.0) | 0.95 |
Macrolide + Fluoroquinolone + Rifampicin | 67 (24.6) | 15 (25.0) | 0.77 |
No anti-legionella therapy | 18 (6.6) | 7 (11.7) | 0.18 |
Oral anti-legionella therapy only | |||
Yesg | 22 (8.1) | 3 (5.0) | 0.40 |
No | 247 (90.8) | 57 (95.0) | 0.40 |