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Table 1 Performance characteristics of the GenoType® MTBDRplus assay.

From: Validation of the GenoType® MTBDRplus assay for detection of MDR-TB in a public health laboratory in Thailand

A. Performance characteristics of the GenoType® MTBDRplusassay for the detection of RIF- and INH-resistance in comparison to drug-susceptibility test results using the MGIT BACTEC 960.

  

INH Resistance

RIF Resistance

  

MGIT AST Result

MGIT AST Result

Specimen Type

GenoType® MTBDR plus Result

+

-

Sensitivity

(%)

Specificity (%)

+

-

Sensitivity (%)

Specificity (%)

AFB+ Sputum

+ (Resistant)

27

0

93.1

100

19

0

100

100

 

- (Sensitive)

2

135

  

0

145

  

Stored Isolate

+

14

0

100

100

6

0

100

100

 

-

0

36

  

0

44

  

All Specimens

+

41

0

95.3

100

25

0

100

100

 

-

2

171

  

0

189

  

B. Performance characteristics of the GenoType ® MTBDR plus assay for the detection of MDR-TB in comparison to drug-susceptibility test results using the MGIT BACTEC 960.

 

MDR-TB

MGIT AST Result

        

Specimen Type

GenoType ® MTBDR plus Result

+

-

Sensitivity

(%)

Specificity (%)

    

AFB+ Sputum

+ (Resistant)

12

0

92.3

100

    
 

- (Sensitive)

1

151

      

Stored Isolate

+

5

0

100

100

    
 

-

0

45

      

All Specimens

+

17

0

94.4

100

    
 

-

1

196

      
  1. + = Resistant; - = Sensitive