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Table 3 Unadjusted relative risk for each selected factor on severe scrub typhus

From: Clinical and laboratory findings associated with severe scrub typhus

Factors Severe scrub typhus (n = 89) Non-severe scrub typhus (n = 119) Odds ratio (CI) Pvalue
Age(year) > 60 71 (79.8%) 57 (47.9%) 4.3 (2.3-8.1) < 0.001
Mean duration from disease onset to effective antibiotic therapy (days) 8.34 ± 5.1 7.11 ± 3.7   0.1
Underlying diseases (Diabetes, Liver cirrhosis, COPD) 6 (6.8%) 4 (3.3%) 2.1(0.6-7.8) 0.25
Headache 74 (83.1) 109 (91.6) 0.5 (0.2-1.1) 0.07
Myalgia 66 (74.2) 95(79.8) 0.7(0.4-1.4) 0.3
Skin rash 78(87.6) 111 (93.3) 0.5 (0.2-1.3) 0.2
Eschar 77 (86.5) 117 (98.3) 0.1 (0.02-0.5) 0.004
WBC count (> 10, 000/mm3) 37 (41.6%) 16 (13.4%) 4.6 (2.3-9.0) < 0.001
Hemoglobin (≤ 10 g/dL) 10 (11.2%) 2 (1.7%) 0.14(0.03-0.63) 0.01
Platelet count (≤ 100, 000/mm3) 28(31.5%) 25(21.0%) 0.58(0.31-1.09) 0.09
AST (>40 IU) 79(88.8%) 108 (90.8%) 1.24(0.50-3.07) 0.64
ALT (>40 IU) 84(94.4%) 106 (89.1%) 1.0 (1.0-1.0) 0.16
ALP (>200 U/L) 19(21.6%) 17 (14.9%) 1.6(0.79-3.3) 0.19
Bilirubin (>1.0 mg/dL) 23(25.8%) 22 (18.5%) 1.54(0.79-2.98) 0.2
Albumin (≤ 3.0 g/dL) 28(31.5%) 6(5.1%) 8.5(3.32-21.64) > 0.001
LDH (>800 U/L) 37(43.0%) 63(53.8%) 0.65(0.37-1.13) 0.13
CPK (>200 U/L) 24(27.9%) 31(26.7%) 1.06(0.57-1.98) 0.85
ADA (<100 IU/L) 13(22.0%) 13(19.4%) 1.17(0.50-2.78) 0.72
Serum creatinine (> 1.4 mg/dL) 31(34.8%) 3(2.5%) 20.7(6.06-70.4) < 0.001
Fibrinogen (≤ 150 mg/dL) 6(7.2%) 3(2.8%) 0.37(0.09-1.51) 0.17
CRP (> 10 mg/dL) 37(44.6%) 29(24.8%) 2.44(1.34-4.46) 0.004
ESR (> 20 mm/hr) 33(39.8%) 41(35.3%) 1.21(0.68-2.16) 0.53
PT (> 15 sec) 2(2.2%) 2(1.7%) 1.31(0.18-9.49) 0.79
aPTT (>40 sec) 9(10.1%) 4 (3.4%) 3.15(0.94-10.59) 0.06
  1. Abbreviations as in Table 1