Skip to main content

Table 2 Type and frequency of mutations described in the pncA promoter region and the region between residues 132 and 142 of the PncAa

From: pncA mutations in clinical Mycobacterium tuberculosisisolates from Korea

Mutation site

Nucleotide change

Amino acid change

Frequency

-16∼-11

AACGTA to GGCAGTT

Mutation in promoter

 

1

-12

T to G

Mutation in promoter

1

-11

A to C

Mutation in promoter

1

-11

A to G

Mutation in promoter

13

-7

T to C

Mutation in promoter

1

394

G to A

Gly132

Ser

2

395

G to A or T

Gly132

Asp or Val

4

398

T to C

Ile133

Thr

1

401

C to T

Ala134

Val

3

403

A to C

Thr135

Pro

2

406

G to C

Asp136

His

1

407

A to G

Asp136

Gly

1

410

A to C or G

His137

Pro or Arg

4

413

G to A or C

Cys138

Thr or Ser

5

415

G to C or A

Val139

Leu or Met

5

416

T to C or G

Val139

Ala or Gly

6

421

C to T

Gln141

termination

1

422

A to C

Gln141

Pro

3

424

A to C or G

Thr142

Pro or Ala

2

425

C to A or T

Thr142

Lys or Met

8

402∼403

CC insertion

Frameshift

1

407∼408

C insertion

Frameshift

1

416∼417

TG deletion

Frameshift

1

395∼411

17-bp deletion

Frameshift

1

  1. a The mutations described here were cited from references [4, 5, 9, 11,12,13,14, 16] and the present study