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Table 1 Pooled data on efficacy

From: Imiquimod for the treatment of genital warts: a quantitative systematic review

  

outcome achieved

  
  

with

  
  

Active

Placebo

  

Outcome

Number of trials

Number/total

Percent (95% CI)

Number/total

Percent (95% CI)

Relative benefit (95% CI)

NNT (95% CI)

Complete clearance of warts

       

In all patients treated with imiquimod (highest dose)

5

153/303

51 (45 to 56)

16/285

6 (3 to 8)

8.3 (5.2 to 13)

2.2 (2.0 to 2.6)

In patients treated with 5% imiquimod

4

128/273

47 (41 to 53)

15/255

6 (3 to 9)

7.3 (4.5 to 12)

2.5 (2.1 to 2.9)

In patients treated with 1% imiquimod

2

34/192

18 (12 to 23)

14/195

7 (4 to 11)

2.4 (1.4 to 4.4)

9.5 (5.9 to 25)

In women treated with imiquimod (highest dose)

3

85/118

72 (64 to 80)

12/112

11(5 to 16)

6.6 (3.8 to 11)

1.6 (1.4 to 2.0)

In men treated with imiquimod (highest dose)

3

61/166

37 (29 to 44)

4/171

2 (1 to 5)

15 (5.8 to 41)

2.9 (2.4 to 3.7)

At least 50% clearance of warts

       

In patients treated with 5% imiquimod

4

197/273

72 (67 to 78)

50/255

20 (15 to 25)

3.6 (2.8 to 4.6)

1.9 (1.7 to 2.2)

In patients treated with 1% imiquimod

2

68/198

34 (28 to 41)

45/195

23 (17 to 29)

1.5 (1.1 to 2.1)

8.1 (4.7 to 30)

In women treated with imiquimod (highest dose)

1

39/46

85 (74 to 95)

15/40

38 (22 to 53)

2.3 (1.5 to 3.4)

2.1 (1.5 to 3.4)

In men treated with imiquimod (highest dose)

2

78/114

68 (60 to 77)

17/117

15 (8 to 21)

4.6 (2.9 to 7.2)

1.9 (1.6 to 2.3)

Warts completely cleared and not recurred

       

In patients treated with 5% imiquimod

3

94/254

37 (31 to 43)

10/253

4 (2 to 6)

9.0 (4.9 to 17)

3.0 (2.5 to 3.8)

In patients treated with 1% imiquimod

2

28/192

15 (10 to 20)

9/195

5 (2 to 8)

2.9 (1.5 to 5.9)

10 (6.4 to 26)

New warts completely cleared

       

In patients treated with 5% imiquimod

2

16/41

39 (24 to 54)

16/78

21 (12 to 30)

2.0 (1.1 to 3.7)

5.4 (2.8 to 91)

  1. Outcomes are reported for various doses of imiquimod and durations of treatment. When 5% and 1% imiquimod was used in a singe trial, the 5% results are compared with placebo unless specified otherwise. Only studies with HIV-negative patients have been pooled CI = confidence interval; NNT = number needed to treat